| T6344 |
Sevelamer hydrochloride
|
152751-57-0
|
98%
|
|
|
Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption....
|
| T77124 |
Osocimab
|
2056878-75-0
|
98%
|
Osocimab
|
|
Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition...
|
| T11661 |
INT-767
|
1000403-03-1
|
98%
|
|
|
INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function fo...
|
| T6053 |
Turofexorate Isopropyl
|
629664-81-9
|
|
|
|
Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
|
| T8471 |
Vonafexor
|
1192171-69-9
|
100%
|
|
|
Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects
|
| T2968 |
Hyodeoxycholic acid
|
83-49-8
|
97.26%
|
|
|
Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.
|
| T7436 |
Cilofexor
|
1418274-28-8
|
98%
|
|
|
Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.
|
| T5574 |
Guggulsterone
|
95975-55-6
|
98%
|
|
|
Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.
|
| T27460 |
GSK2324
|
1020567-30-9
|
98.50%
|
|
|
GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.
|
| T29078 |
Ursodeoxycholic acid sodium
|
2898-95-5
|
98.55%
|
|
|
Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeox...
|
| T8895 |
Altenusin
|
31186-12-6
|
98.97%
|
|
|
Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.
|
| T4379 |
Tropifexor
|
1383816-29-2
|
99.3%
|
|
|
Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.
|
| T6690 |
T0901317
|
293754-55-9
|
99.43%
|
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|
| T31587 |
DY268
|
1609564-75-1
|
99.43%
|
|
|
DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 =...
|
| T2939 |
Forskolin
|
66575-29-9
|
99.57%
|
|
|
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces auto...
|
| T2015 |
Fexaramine
|
574013-66-4
|
99.61%
|
|
|
Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.
|
| T11428 |
Glyco-Obeticholic acid
|
863239-60-5
|
99.77%
|
|
|
Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).
|
| T7886 |
Nidufexor
|
1773489-72-7
|
99.79%
|
|
|
Nidufexor is an agonist for the farnesoid X receptor (FXR).
|
| T13092 |
Tauro-Obeticholic acid
|
863239-61-6
|
99.82%
|
|
|
Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).
|
| TQ0252 |
BAR502
|
1612191-86-2
|
99.91%
|
|
|
BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).
|
