T10608 |
BRD5648
|
2056261-42-6
|
98%
|
|
BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM) and can be used in acute myeloid leukemia ...
|
T9987 |
GSK3-IN-1
|
478482-74-5
|
98%
|
|
GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.
|
TN4583 |
Moringin
|
73255-40-0
|
98%
|
|
Moringin is an isothiocyanate obtained from myrosinase-mediated hydrolysis of the glucosinolate precursor glucoMoringin present in Moringa oleifera seeds. Moring...
|
T9611 |
PF-04802367
|
1962178-27-3
|
98%
|
|
PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay. It s...
|
T77671 |
GSK3a-IN-38
|
1062138-03-7
|
98%
|
|
GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.
|
T2166 |
TWS119
|
601514-19-6
|
|
|
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
|
T14072 |
A-443654
|
552325-16-3
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T17019 |
TCS 21311
|
1260181-14-3
|
|
|
TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, resp...
|
T2873 |
Ginsenoside Rg2
|
52286-74-5
|
|
|
Ginsenoside Rg2 (Chikusetsusaponin I) is one of the major active components of ginseng, act as an NF-κB inhibitor.
|
T69188 |
Aloisine B
|
496864-14-3
|
95.15%
|
|
Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively. Aloisine B has antiv...
|
T11471 |
GSK-3β inhibitor 2
|
1702428-31-6
|
95.69%
|
|
GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = ...
|
T2608 |
CHIR-98014
|
252935-94-7
|
97.09%
|
|
CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
|
T64366 |
GSK3-IN-4
|
748145-19-9
|
97.1%
|
|
GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.
|
T6187 |
TDZD-8
|
327036-89-5
|
97.13%
|
|
TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.
|
T6787 |
BIO-acetoxime
|
667463-85-6
|
97.28%
|
|
BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.
|
T2378 |
RGB-286638 free base
|
784210-88-4
|
97.29%
|
|
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3...
|
T61809 |
GSK-3β inhibitor 11
|
536731-65-4
|
97.33%
|
|
GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM. This compoun...
|
T35554 |
GSK-3β inhibitor 3
|
1448990-73-5
|
97.53%
|
|
GSK-3β inhibitor 3 is a covalent inhibitor (IC50: 6.6 μM) of glycogen synthase kinase 3β (GSK-3β) that is potent, selective, and irreversible.GSK-3β inhibitor 3 ...
|
T6169 |
Indirubin
|
479-41-4
|
97.86%
|
|
Indirubin (Couroupitine B) is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
|
T7473 |
5-Bromoindole
|
10075-50-0
|
98%
|
|
5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate
|