| T33412 |
MitoPQ
|
1821370-28-8
|
98%
|
|
|
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhi...
|
| T23552 |
YZ9
|
6093-71-6
|
98%
|
|
|
PFKFB3 inhibitor
|
| T3105 |
PFK-158
|
1462249-75-7
|
|
|
|
PFK-158 is an effective and specific inhibitor PFKFB3.
|
| T14212 |
AMG-1694
|
1361217-07-3
|
97.97%
|
|
|
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby...
|
| T77784 |
WAY-297848
|
404360-27-6
|
98.19%
|
|
|
WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.
|
| T8986 |
ML198
|
1380716-06-2
|
98.31%
|
|
|
ML198 is a novel activator and non-inhibitory chaperone of glucocerebrosidase. ML198 serves as a starting point to develop a novel approach towards small molecul...
|
| T8990 |
ML266
|
1462267-08-8
|
98.45%
|
|
|
ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase ac...
|
| T12056 |
MK-0941 free base
|
752240-01-0
|
98.55%
|
|
|
MK-0941 free base is an orally active glucokinase activator, exhibiting strong glucose-lowering activity and is a potential therapeutic agent for treatment of ty...
|
| T60048 |
WAY-640509
|
851185-20-1
|
98.59%
|
|
|
WAY-640509 is a glucocerebrosidase inhibitor.
|
| T16479 |
PF-04937319
|
1245603-92-2
|
98.61%
|
|
|
PF-04937319 is an activator of glucokinase (EC50 =154.4 μM). PF-04937319 maintains glucose-lowering efficacy while mitigating the risk of hypoglycemia observed ...
|
| T30142 |
ARRY-403
|
1138669-65-4
|
98.69%
|
|
|
ARRY-403 is a novel glucokinase activator that reduces fasting and postprandial blood glucose in patients with type 2 diabetes.
|
| T3260 |
(E)-3PO
|
13309-08-5
|
98.8%
|
|
|
(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.
|
| T0714 |
Oxfendazole
|
53716-50-0
|
98.81%
|
|
|
Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.
|
| TQ0055 |
AMG-3969
|
1361224-53-4
|
98.89%
|
|
|
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
|
| T14365 |
AZ PFKFB3 26
|
1704740-52-2
|
98.91%
|
|
|
AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
|
| T2455 |
PFK-015
|
4382-63-2
|
98.94%
|
|
|
PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).
|
| T3104L |
(1S,2R)-Globalagliatin
|
2514278-46-5
|
99%
|
|
|
(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.
|
| T67874 |
PFKFB3-IN-2
|
794552-84-4
|
99.12%
|
|
|
PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. Anti-sense treatment against PFKFB3 was shown to reduce tumor growth ...
|
| T4049 |
Genz-123346 free base
|
491833-30-8
|
99.23%
|
|
|
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
|
| T19500 |
Palmitelaidic Acid
|
10030-73-6
|
99.36%
|
|
|
Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.
|
