ホーム 計算ツール
代理店ログイン

Guanylate cyclase

Guanylate cyclase (also known as guanyl cyclase, guanylyl cyclase, or GC) is a lyase enzyme that converts guanosine triphosphate (GTP) to cyclic guanosine monophosphate (cGMP) and pyrophosphate. It is often part of the G protein signaling cascade that is activated by low intracellular calcium levels and inhibited by high intracellular calcium levels. In response to calcium levels, guanylate cyclase synthesizes cGMP from GTP. cGMP keeps cGMP-gated channels open, allowing for the entry of calcium into the cell.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T6775 BAY 41-2272 256376-24-6 98%
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
T4381 Lificiguat 170632-47-0 98%
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha)...
T6888 Methylene Blue 61-73-4 98%
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dy...
T76769 Indusatumab 1497400-26-6 98%
Indusatumab
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.
T1984 Cinaciguat 329773-35-5 98%
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensate...
T16808 Runcaciguat 1402936-61-1 98%
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies abou...
T0006 Methylene Blue trihydrate 7220-79-3 98%
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water o...
T6991 Nitroprusside disodium dihydrate 13755-38-9
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.
T11424 Glutaminyl Cyclase Inhibitor 1 2110449-60-8 100%
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
T9080 Plecanatide 467426-54-6 97.51%
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
T11852 リナクロチド 851199-59-2 97.93%
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
T19777 ODQ 41443-28-1 98.46%
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
T21576 LY83583 91300-60-6 98.71%
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
T34648 Sinitrodil 143248-63-9 99%
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T16569 Praliciguat 1628730-49-3 99.05%
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also...
T7201 Nelociguat 625115-52-8 99.15%
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxi...
T16383 Olinciguat 1628732-62-6 99.33%
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assay...
T16344 NS-2028 204326-43-2 99.44%
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
T21712 BAY 41-8543 256498-66-5 99.49%
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
T67734 MCUF-651 2747162-85-0 99.57%
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
BAY 41-2272
T6775
BAY 41-2272 is a direct and NO-independent soluble guanylate cyclase (sGC) stimulator.
Lificiguat
T4381
Lificiguat (YC-1) is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase(sGC) and an inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha)...
Methylene Blue
T6888
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dy...
Indusatumab
T76769
Indusatumab (5F9 Monoclonal antibody) is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody that can be used to synthesize antibody-drug conjugate.
Cinaciguat
T1984
Cinaciguat (BAY 58-2667) (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in Clinicalal development for acute decompensate...
Runcaciguat
T16808
Runcaciguat is a soluble guanylate cyclase stimulator. Runcaciguat combines with selective partial adenosine A1 receptor agonists and can be used in studies abou...
Methylene Blue trihydrate
T0006
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water o...
Nitroprusside disodium dihydrate
T6991
Nitroprusside disodium dihydrate (Sodium Nitroprusside Dihydrate) is a potent vasodilator working through releasing NO spontaneously in blood.
Glutaminyl Cyclase Inhibitor 1
T11424
Glutaminyl Cyclase Inhibitor 1 is a glutaminyl cyclase inhibitor (IC50: 0.5 μM) that can be used to study neurological disorders.
Plecanatide
T9080
Plecanatide acetate is an analogue of Uroguanylin. It is an orally active guanylate cyclase-C (GC-C) receptor agonist.
Linaclotide
T11852
Linaclotide developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, and is a potent and selective guan...
ODQ
T19777
ODQ is an effective and selective soluble guanylyl cyclase (sGC) inhibitor.
LY83583
T21576
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
Sinitrodil
T34648
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
Praliciguat
T16569
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also...
Nelociguat
T7201
Nelociguat (BAY60-4552)(BAY60-4552) is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxi...
Olinciguat
T16383
Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator. It also has concentration-dependent stimulation of sGC in purified rat and human enzyme assay...
NS-2028
T16344
NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor (IC50: 30 nM and 200 nM for basal and NO-stimulated enzyme activity). It is commonly used ...
BAY 41-8543
T21712
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC).
MCUF-651
T67734
MCUF-651 is a guanylyl cyclase A receptor positive allosteric modulators, EC50=0.45 μM.
1 2