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HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T1819 Nexturastat A 1403783-31-2 98%
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T11329 FT895 2225728-57-2 98%
FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.
T2294 BG45 926259-99-6 98%
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T3509 ACY-738 1375465-91-0 98%
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
T17028 Tefinostat 914382-60-8 98%
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the int...
T9745 Elevenostat 1454902-97-6 98%
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
T10777 CG347B 1598426-03-9 98%
CG347B is a selective inhibitor of HDAC6.
T14305 Apicidin 183506-66-3 98%
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inh...
T77664 KH16 98%
KH16 is a potent HDAC inhibitor that specifically targets class I HDACs (HDAC1, HDAC2 and HDAC3) with IC50 values between 6 and 34 nM. KH16 is able to stimulate ...
T3206 NKL 22 537034-15-4 98%
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
TQ0074 ACY-775 1375466-18-4 98%
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
T8517 Belinostat 866323-14-0 98%
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
T4481 Tucidinostat 1616493-44-7 98%
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and...
T16545 Pivanex 122110-53-6 98%
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein ...
T26897 BRD2492 1821669-43-5 98%
BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, H...
T3204 BML-210 537034-17-6 98%
BML-210 (CAY10433) is a new-type HDAC inhibitor.
T5886 4-Phenylbutyric acid 1821-12-1 98%
4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.
T2025 HDAC-IN-7 743420-02-2 98%
HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3...
T6S0033 Crotonoside 1818-71-9 98%
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestin...
T21551 2-hexyl-4-Pentynoic Acid 96017-59-3 98%
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
Nexturastat A
T1819
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
FT895
T11329
FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.
BG45
T2294
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
ACY-738
T3509
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
Tefinostat
T17028
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the int...
Elevenostat
T9745
Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
CG347B
T10777
CG347B is a selective inhibitor of HDAC6.
Apicidin
T14305
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inh...
KH16
T77664
KH16 is a potent HDAC inhibitor that specifically targets class I HDACs (HDAC1, HDAC2 and HDAC3) with IC50 values between 6 and 34 nM. KH16 is able to stimulate ...
NKL 22
T3206
NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.
ACY-775
TQ0074
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
Belinostat
T8517
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
Tucidinostat
T4481
Tucidinostat (Chidamide) is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and...
Pivanex
T16545
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein ...
BRD2492
T26897
BRD2492 is a selective and potent dual inhibitor of HDAC1 and HDAC2 with potential anticancer, antitumour and antiproliferative activities, inhibiting HDAC1/2, H...
BML-210
T3204
BML-210 (CAY10433) is a new-type HDAC inhibitor.
4-Phenylbutyric acid
T5886
4-Phenylbutyric acid (Benzenebutyric acid) is an inhibitor of HDAC,and is an antineoplastic agent.
HDAC-IN-7
T2025
HDAC-IN-7 (HBI-8000) (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable inhibitor of HDAC enzymes class I (HDAC1/2/3...
Crotonoside
T6S0033
1. Crotonoside (Isoguanosine) has much more active than adenosine in reducing the blood pressure in rabbits and cats, in decreasing the tone of isolated intestin...
2-hexyl-4-Pentynoic Acid
T21551
2-hexyl-4-Pentynoic Acid, a valproic acid (VPA) derivatives, is a potent and robust HDACs inhibitor with IC50 value of 13 μM.
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