HIF

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. It is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator of cellular and developmental response to hypoxia. The dysregulation and overexpression of HIF1A by either hypoxia or genetic alternations have been heavily implicated in cancer biology, as well as a number of other pathophysiologies, specifically in areas of vascularization and angiogenesis, energy metabolism, cell survival, and tumor invasion. Two other alternative transcripts encoding different isoforms have been identified.

Cat. No.	製品名	CAS No.	Purity
T22022	Adaptaquin	385786-48-1	98%
T22022	Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T11562	HIF-2α-IN-3	313964-19-1	98%
T11562	HIF-2α-IN-3 is an allosteric inhibitor of HIF-2α (IC50: 0.4 μM; KD: 1.1 μM) with anticancer activity.
T15482	HIF-2α-IN-1	1799948-06-3	98%
T15482	HIF-2α-IN-1 is a potent HIF-2α inhibitor with IC50 values less than 500 nM.
T21494	Oligomycin	1404-19-9	98%
T21494	Oligomycin is an antifungal antibiotic that is an inhibitor of H+-ATP synthetase. The Oligomycin blocks oxidative phosphorylation and the electron transport chai...
T1939	DMOG	89464-63-1
T1939	DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
TQ0121	VH-298	2097381-85-4	100%
TQ0121	VH-298 is a potent inhibitor of VHL that stabilizes HIF-α and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-α protein...
T13925	THS-044	62054-67-5	100%
T13925	THS-044 (N-[2-Nitro-4-(Trifluoromethyl)phenyl]morpholin-4-Amine) binding stabilizes the HIF2α PAS-B folded state with a kd of 2 μM and regulates HIF2 activity in...
T17009	TC-S 7009	1422955-31-4	100%
T17009	TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM). The affinity of TC-S 7009 to HIF-2α was higher than that of HIF-1α (Kd >> 5μM). TC-S 7009 disru...
T7802	M1001	874590-32-6	100%
T7802	M1001 is a HIF-2α agonist.
T4S1551	Cinnamaldehyde	104-55-2	85%
T4S1551	1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB...
T11589	Hydroxycitric acid tripotassium hydrate	6100-05-6	95%
T11589	Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
T3027	Sodium Aescinate	20977-05-3	95.17%
T3027	Sodium Aescinate (Escin sodium salt) is extracted from Aesculus wilsonii.
T6961	PX-478	685898-44-6	97%
T6961	PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
T29797	AKB-6899	1007377-55-0	97.11%
T29797	AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
T36711	FM19G11	329932-55-0	97.28%
T36711	FM19G11 is an inhibitor of hypoxia inducible factor (HIF) α-subunit (IC50 = 80 nM in hypoxia induced luciferase assay).
T5537	IDF-11774	1429054-28-3	98%
T5537	IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T15396	GN44028	1421448-26-1	98.20%
T15396	GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 ...
T67831	HIF-2α agonist 2	2750141-15-0	98.32%
T67831	HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
T61349	HIF-1α-IN-2	2762315-06-8	98.45%
T61349	HIF-1α-IN-2 is a novel and highly potent HIF-1α inhibitor with anticancer and antitumor activity that inhibits the expression of HIF-1α and VEGF in a dose-depend...
T4S0800	Demethyleneberberine	25459-91-0	98.54%
T4S0800	Demethyleneberberine, which is composed of a potential antioxidant structure, could penetrate the membrane of mitochondria and accumulate in mitochondria either ...