| T9627 |
PHD-1-IN-1
|
2009343-14-8
|
98%
|
|
|
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
|
| T1939 |
DMOG
|
89464-63-1
|
|
|
|
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
|
| T4106 |
MK-8617
|
1187990-87-9
|
|
|
|
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
|
| T6381 |
Amifostine trihydrate
|
112901-68-5
|
|
|
|
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
|
| T50099 |
HIF-2α-IN-4
|
882268-69-1
|
|
|
|
HIF-2a translation inhibitor is a compound used as a molecular building block.
|
| T1141 |
Fenbendazole
|
43210-67-9
|
100%
|
|
|
Fenbendazole (Fenbendazol) is an antinematodal benzimidazole used in veterinary medicine.
|
| T7802 |
M1001
|
874590-32-6
|
100%
|
|
|
M1001 is a HIF-2α agonist.
|
| T1101 |
Minocycline hydrochloride
|
13614-98-7
|
100%
|
|
|
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infe...
|
| T11589 |
Hydroxycitric acid tripotassium hydrate
|
6100-05-6
|
95%
|
|
|
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-...
|
| T6961 |
PX-478
|
685898-44-6
|
97%
|
|
|
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-...
|
| T29797 |
AKB-6899
|
1007377-55-0
|
97.11%
|
|
|
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macr...
|
| T21653 |
1,4-DPCA
|
331830-20-7
|
97.75%
|
|
|
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HI...
|
| T3180 |
JNJ-42041935
|
1193383-09-3
|
98%
|
|
|
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
|
| T5537 |
IDF-11774
|
1429054-28-3
|
98%
|
|
|
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
|
| TL0001 |
Dencichine
|
5302-45-4
|
98%
|
|
|
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggre...
|
| T5684 |
Ethyl 3,4-dihydroxybenzoate
|
3943-89-3
|
98%
|
|
|
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
|
| T0256 |
Citric acid trilithium salt tetrahydrate
|
6080-58-6
|
98%
|
|
|
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiat...
|
| T67831 |
HIF-2α agonist 2
|
2750141-15-0
|
98.32%
|
|
|
HIF-2α agonist 2 is an HIF-2α agonist with an EC50 value of 1.68 μM for HIF-2α. HIF-2α agonist 2 can promote the stability of the ARNT A/B ring in the 3z structu...
|
| T2445 |
FG-2216
|
223387-75-5
|
98.32%
|
|
|
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo ...
|
| T1152 |
Albendazole
|
54965-21-8
|
98.76%
|
|
|
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
|
