| T22814 |
GSA-10
|
300833-95-8
|
98%
|
|
|
Smoothened (Smo) receptor agonist
|
| T2666 |
Taladegib
|
1258861-20-9
|
98%
|
|
|
Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antin...
|
| T3460 |
HhAntag
|
496794-70-8
|
|
|
|
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity....
|
| T4211 |
SAG hydrochloride (912545-86-9(free base))
|
2095432-58-7
|
|
|
|
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
|
| T1094 |
Tolnaftate
|
2398-96-1
|
100%
|
|
|
Tolnaftate (NP-27) is a synthetic antifungal agent.
|
| T40465 |
SAG dihydrochloride
|
2702366-44-5
|
100%
|
|
|
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway. It als...
|
| T1011 |
Itraconazole
|
84625-61-6
|
100%
|
|
|
Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes required for ERGOSTEROL synthesis.
|
| T14965 |
Ciliobrevin D
|
1370554-01-0
|
100%
|
|
|
Ciliobrevin D is a AAA+ ATPase motor cytoplasmic dynein inhibitor. Ciliobrevin D inhibits Hedgehog (Hh) signaling and primary cilia formation and it also inhibit...
|
| T23370 |
SMANT hydrochloride
|
1177600-74-6
|
100%
|
|
|
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
|
| T22089 |
HPI 1
|
599150-20-6
|
94.4%
|
|
|
HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5...
|
| T15019L |
CUR61414 hydrochloride
|
|
95.22%
|
|
|
CUR61414 hydrochloride is a potent and cell permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM). CUR61414 hydrochloride is a small-molecule amin...
|
| T3156 |
Ciliobrevin A
|
302803-72-1
|
97.10%
|
|
|
Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
|
| T15019 |
CUR61414
|
334998-36-6
|
97.34%
|
|
|
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds to smoothened (Ki = 44 nM).
|
| T6514 |
Glasdegib
|
1095173-27-5
|
98%
|
|
|
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.
|
| T3070 |
GANT 61
|
500579-04-4
|
98%
|
|
|
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.
|
| T1810 |
Purmorphamine
|
483367-10-8
|
98.11%
|
|
|
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to Smo. It also is an inducer of os...
|
| T2825 |
Cyclopamine
|
4449-51-8
|
98.55%
|
|
|
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the group of steroidal jerveratrum alkaloids.
|
| T63429 |
SMO-IN-2
|
1822355-27-0
|
98.64%
|
|
|
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medull...
|
| T14188 |
ALLO-2
|
1357350-60-7
|
98.67%
|
|
|
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
|
| T21325 |
TAK-441
|
1186231-83-3
|
98.79%
|
|
|
TAK-441 is an orally active inhibitor of Hedgehog signaling(IC50 = 4.4 nM) with potent antitumor activity. TAK-441 suppresses transcription factor Gli1 mRNA expr...
|
