| T28036 |
MI-2-2
|
1454920-20-7
|
98%
|
|
|
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
|
| T4393 |
MS049 2HCl (1502816-23-0(free base))
|
T4393
|
98%
|
|
|
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220...
|
| T8510 |
CPI-1205
|
1621862-70-1
|
98%
|
|
|
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
|
| T6803 |
Chaetocin
|
28097-03-2
|
98%
|
|
|
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a an...
|
| T36798 |
SW2_110A
|
2579696-95-8
|
98%
|
|
|
SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selectiv...
|
| T13954 |
UNC6852
|
2688842-08-0
|
98%
|
|
|
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
|
| T1905 |
EPZ005687
|
1396772-26-1
|
98%
|
|
|
EPZ005687 is a potent and selective inhibitor of EZH2.
|
| T16072 |
MI-538
|
1857417-10-7
|
98%
|
|
|
MI-538 is an interaction between menin and MLL fusion proteins inhibitor(IC50 of 21 nM).
|
| T7697 |
BIX-01294
|
935693-62-2
|
|
|
|
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
|
| T4021L |
UNC3866 TFA(1872382-47-2 free base)
|
1872382-48-3
|
|
|
|
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
|
| T4013 |
SGC2085 HCl
|
1821908-49-9
|
|
|
|
SGC2085 is a potent and selective coactivator associated arginine methyltransferase 1 (CARM1) Inhibitor with an IC50 of 50 nM and more than undred-fold selectivi...
|
| T22325 |
EPZ020411 hydrochloride
|
2070015-25-5
|
100%
|
|
|
EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.
|
| T22322 |
EEDi-5285
|
2488952-40-3
|
100%
|
|
|
EEDi-5285, an orally active and highly potent inhibitor targeting embryonic ectoderm development (EED) protein, exhibits anti-cancer activity. It demonstrates ex...
|
| T0174 |
Cyproheptadine hydrochloride sesquihydrate
|
41354-29-4
|
100%
|
|
|
Cyproheptadine hydrochloride sesquihydrate (Peritol), an antihistamine, is an antagonist of serotonin and histamine2.
|
| TQ0232 |
UNC0646
|
1320288-17-2
|
100%
|
|
|
UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646(UNC 0646) p...
|
| T2643 |
MI-3
|
1271738-59-0
|
100%
|
|
|
MI-3 (Menin-MLL Inhibitor) (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).
|
| T77697 |
BML-278
|
120533-76-8
|
100%
|
|
|
BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can...
|
| T5484 |
GSK467
|
1628332-52-4
|
100%
|
|
|
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
|
| T36975 |
EZM0414 TFA
|
2411759-92-5
|
96.2%
|
|
|
EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.
|
| T21826 |
TC-E 5003
|
17328-16-4
|
97.01%
|
|
|
TC-E 5003 (NSC-30176) is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.
|
