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Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T3257 UNC0638 1255580-76-7 98%
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ep...
T28036 MI-2-2 1454920-20-7 98%
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
T4393 MS049 2HCl (1502816-23-0(free base)) T4393 98%
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220...
T5322 BCI-121 432529-82-3 98%
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
T0174 Cyproheptadine hydrochloride sesquihydrate 41354-29-4 98%
Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
T3084 SGC707 1687736-54-4 98%
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
T6803 Chaetocin 28097-03-2 98%
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a an...
T16886 Sinefungin 58944-73-3 98%
Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin i...
T36798 SW2_110A 2579696-95-8 98%
SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selectiv...
T15194 EBI-2511 2098546-05-3 98%
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
T6879 LLY-507 1793053-37-8 98%
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
T13954 UNC6852 2688842-08-0 98%
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
T2097 C-7280948 587850-67-7 98%
C-7280948 is a PRMT1 inhibitor.
T4021 UNC3866 1872382-47-2 98%
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T9584 UNC6934 2561494-77-5 98%
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
T2354 UNC 0631 1320288-19-4 98%
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T8879 MR837 1210906-48-1 98%
ZINC30303842 is a NSD2-PWWP1 antagonist.
T4021L UNC3866 TFA(1872382-47-2 free base) 1872382-48-3 98%
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
T1905 EPZ005687 1396772-26-1 98%
EPZ005687 is a potent and selective inhibitor of EZH2.
T2643 MI-3 1271738-59-0 98%
MI-3 (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).
UNC0638
T3257
UNC0638 is an inhibitor of β-protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of ep...
MI-2-2
T28036
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
MS049 2HCl (1502816-23-0(free base))
T4393
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220...
BCI-121
T5322
BCI-121 is a substrate-competitive SMYD3 inhibitor that inhibits the proliferation of the cancer cell.
Cyproheptadine hydrochloride sesquihydrate
T0174
Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
SGC707
T3084
SGC707 is a potent, selective, and cell-active allosteric inhibitor of PRMT3.
Chaetocin
T6803
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a an...
Sinefungin
T16886
Sinefungin is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin i...
SW2_110A
T36798
SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selectiv...
EBI-2511
T15194
EBI-2511 is a highly potent and orally active inhibitor of EZH2 (IC50: 6 nM in Pfeffiera cell lines).
LLY-507
T6879
LLY-507 is an effective, cell-active, and specific inhibitor of protein-lysine Methyltransferase SMYD2.
UNC6852
T13954
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
C-7280948
T2097
C-7280948 is a PRMT1 inhibitor.
UNC3866
T4021
UNC3866 is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
UNC6934
T9584
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
UNC 0631
T2354
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
MR837
T8879
ZINC30303842 is a NSD2-PWWP1 antagonist.
UNC3866 TFA(1872382-47-2 free base)
T4021L
UNC3866 TFA is a potent antagonist of the CBX7-H3 interaction as determined by AlphaScreen.
EPZ005687
T1905
EPZ005687 is a potent and selective inhibitor of EZH2.
MI-3
T2643
MI-3 (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).
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