T12939 |
SMYD2-IN-1
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SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
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T11436 |
GNA002
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GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
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T22325 |
EPZ020411 hydrochloride
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EPZ020411 hydrochloride is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.
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T11084 |
Dot1L-IN-5
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Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein ( DOT1L ) inhibitor with an IC 50 SPA DOT1L of 0.17 nM [1].
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TN5097 |
Tanshindiol C
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Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
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T1987 |
PFI-2
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PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
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T10427 |
AZ505 ditrifluoroacetate
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AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
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T27133 |
DCLX069
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DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 occupies the SAM binding pocket to exert the inhibitory effect. DCLX069 effectively blocks cell prolif...
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T11185 |
EML741
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EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
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T11082 |
Dot1L-IN-2
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Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
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T10882 |
CPUY074020
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CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
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T4334 |
EPZ020411 2HCl (1700663-41-7(free base))
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EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
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T22342 |
GSK3368715 3HCl
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GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
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T13279 |
Valemetostat tosylate
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Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
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T6292 |
3-Deazaneplanocin A
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3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
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T11500 |
GSK3368715
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GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
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T2354 |
UNC 0631
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UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
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TN5096 |
Tanshindiol B
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Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
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T11500L |
GSK3368715 dihydrochloride
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GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
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T12541 |
PRMT5-IN-1
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PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
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T12428 |
PF-06726304 acetate
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PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
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T16577 |
PRMT5-IN-2
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PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
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T15240 |
Tazemetostat trihydrochloride
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Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
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T9700 |
EZH2-IN-2
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EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM (Patent WO2018133795A1, Compound Example 69).
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T3081L |
EPZ004777 hydrochloride
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EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
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T6810 |
CPI-360
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CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
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T11083 |
Dot1L-IN-4
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Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
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T12940 |
SMYD3-IN-1
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SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
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T11081 |
Dot1L-IN-1
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The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
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T6360 |
3-deazaneplanocin A HCl
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3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
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T13954 |
UNC6852
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UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
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T10840L |
CM-579
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CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.
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T6803 |
Chaetocin
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Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a an...
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T40254 |
MRTX-1719
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MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.
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T9584 |
UNC6934
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UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
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T28036 |
MI-2-2
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MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
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T2643 |
MI-3
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MI-3 (Menin-MLL Inhibitor) is an effective inhibitor of Menin-MLL interaction (IC50: 648 nM).
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T29231 |
ZLD1039
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ZLD1039 is a potent, highly selective, and orally bioavailable EZH2 inhibitor. ZLD1039 shows potent and concentration-dependent inhibition of PRC2 enzymatic acti...
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T9742 |
SETDB1-TTD-IN-1
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SETDB1-TTD-IN-1 is a potent, selective and endogenous binder competitive inhibitor of SETDB1-TTD with a Kd of 88 nM.
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T9969 |
EZM0414
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EZM0414 is a potent, selective, orally bioavailable inhibitor of SETD2 ( IC 50 =18 nM in SETD2 biochemical assay; IC 50 =34 nM in cellular assay). EZM0414 can be...
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T10205 |
A-395
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A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC5...
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T60002 |
Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate
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Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anti...
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T10682L |
CARM1-IN-1
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CARM1-IN-1 is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.
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T7305 |
JQEZ5
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JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
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T9399 |
Menin-MLL inhibitor 20
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Menin-MLL inhibitor 20 is an irreversible inhibitor of menin-MLL interaction with antitumor activities (WO2020142557A1, compound 6).
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T5484 |
GSK467
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GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
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TQ0232 |
UNC0646
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UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently b...
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T0174 |
Cyproheptadine hydrochloride sesquihydrate
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Cyproheptadine hydrochloride sesquihydrate, an antihistamine, is an antagonist of serotonin and histamine2.
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T21826 |
TC-E 5003
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TC-E 5003 is a selective inhibitor of PRMT1 with IC50 of 1.5 μM.
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T5745 |
GSK3326595
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GSK3326595 is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).
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