| T28036 |
MI-2-2
|
1454920-20-7
|
98%
|
|
|
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
|
| T7697 |
BIX-01294
|
935693-62-2
|
98%
|
|
|
BIX-01294 is an G9a Histone Methyltransferase inhibitor(IC50 : 1.9 μM).
|
| T3458 |
EED226
|
2083627-02-3
|
98%
|
|
|
EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
|
| T4393 |
MS049 2HCl (1502816-23-0(free base))
|
T4393
|
98%
|
|
|
MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220...
|
| T62957 |
MRK-740
|
2387510-80-5
|
98%
|
|
|
MRK-740 is a potent and selective inhibitor of PRDM9 histone methyltransferase.MRK-740 inhibits other histone methyltransferases and inhibits PRDM9-dependent H3K...
|
| T8510 |
CPI-1205
|
1621862-70-1
|
98%
|
|
|
CPI-1205 is a highly potent and selective inhibitor of EZH2(IC50 : 0.002 μM, EC50 : 0.032 μM) .
|
| T64043 |
EZH2-IN-13
|
1403255-41-3
|
98%
|
|
|
EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.
|
| T6803 |
Chaetocin
|
28097-03-2
|
98%
|
|
|
Chaetocin, a natural product from Chaetomium species, is a histone methyltransferase inhibitor with IC50 of 0.8 μM, 2.5 μM and 3 μM for dSU(VAR)3-9, mouse G9a an...
|
| T36798 |
SW2_110A
|
2579696-95-8
|
98%
|
|
|
SW2_110A is a cell-permeable, selective chromosome group 8 chromosome domain (CBX8 ChD) inhibitor with a Kd of 800 nM. In vitro, SW2_110A is 5-fold more selectiv...
|
| T13954 |
UNC6852
|
2688842-08-0
|
98%
|
|
|
UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.
|
| T6059 |
GSK343
|
1346704-33-3
|
98%
|
|
|
GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity against othe...
|
| T13780 |
MS1943
|
2225938-17-8
|
98%
|
|
|
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
|
| T36975 |
EZM0414 TFA
|
2411759-92-5
|
98%
|
|
|
EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.
|
| T72979 |
LEM-14-1189
|
2987501-17-5
|
98%
|
|
|
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with ...
|
| T11500L |
GSK3368715 dihydrochloride
|
1628925-77-8
|
98%
|
|
|
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with antica...
|
| T23284 |
Ryuvidine
|
265312-55-8
|
98%
|
|
|
Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and ...
|
| T60777 |
EM127
|
1886879-71-5
|
98%
|
|
|
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional re...
|
| T61338 |
MS023 dihydrochloride
|
1992047-64-9
|
98%
|
|
|
MS023 dihydrochloride (MS023 2HCl) is a selective, cytosolic and highly potent inhibitor of human type I protein arginine methyltransferases (PRMTs) with antitum...
|
| T40254 |
MRTX-1719
|
2630904-45-7
|
98%
|
|
|
MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells.
|
| T8879 |
MR837
|
1210906-48-1
|
98%
|
|
|
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
|
