| T67947 |
WDR5-0102
|
824960-50-1
|
97.16%
|
|
|
WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4...
|
| T10682L |
CARM1-IN-1
|
1020399-49-8
|
97.35%
|
|
|
CARM1-IN-1 (CARM1-IN-7G) is a selective inhibitor of CARM1 with IC50 of 8.6 μM. CARM1-IN-1 shows weak activity against PRMT1 and SET7 with IC50 > 600 μM.
|
| T9700 |
EZH2-IN-2
|
2238821-31-1
|
97.42%
|
|
|
EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM.
|
| T5745 |
GSK3326595
|
1616392-22-3
|
97.43%
|
|
|
GSK3326595 (EPZ015938) is an inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50:6.2 nM.).
|
| T2649 |
Menin-MLL inhibitor MI-2
|
1271738-62-5
|
97.46%
|
|
|
Menin-MLL inhibitor MI-2 (MI2) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM.
|
| T5605 |
EZM 2302
|
1628830-21-6
|
97.47%
|
|
|
EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).
|
| T9102 |
WM-3835
|
2229025-70-9
|
97.47%
|
|
|
WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferati...
|
| T3099 |
Pinometostat
|
1380288-87-8
|
97.56%
|
|
|
Pinometostat (EPZ-5676) has been used in trials studying the treatment of Leukemia, Acute Leukemias, Acute Myeloid Leukemia, Myelodysplastic Syndrome, and Acute ...
|
| T60777 |
EM127
|
1886879-71-5
|
97.61%
|
|
|
EM127 is a highly selective and potent covalent inhibitor of SMYD3 with a KD value of 13 μM.EM127 inhibits ERK1/2 phosphorylation and inhibits transcriptional re...
|
| T17203 |
UNC0224
|
1197196-48-7
|
97.61%
|
|
|
UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.
|
| T8838 |
CCI-007
|
939228-52-1
|
97.81%
|
|
|
CCI 007 is a selective inhibitor of MLL-r, CALM-AF10 and SET-NUP214 leukemia with IC50 of 3.5 uM against MLL-r leukemia cell line PER-485
|
| T10205 |
A-395
|
2089148-72-9
|
97.82%
|
|
|
A-395 is an antagonist of polycomb repressive complex 2 (PRC2) protein-protein interactions that potently inhibits the trimeric PRC2 complex (EZH2-EED-SUZ12, IC5...
|
| T12430 |
PF-06821497
|
1844849-10-0
|
97.88%
|
|
|
PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.
|
| TQ0263 |
EPZ031686
|
1808011-22-4
|
97.91%
|
|
|
EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
|
| T72979 |
LEM-14-1189
|
2987501-17-5
|
97.98%
|
|
|
Lem-14-1189, a LEM-14 derivative, is a potent NSD inhibitor of the nuclear receptor binding SET domain, and has inhibitory effects on NSD1, NSD2, and NSD3, with ...
|
| T4378 |
MS049
|
1502816-23-0
|
98%
|
|
|
MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.
|
| T7378 |
BRD9539
|
1374601-41-8
|
98%
|
|
|
BRD9539 is an inhibitor of euchromatin histone methyltransferase 2 (EHMT2), also known as G9a, with an IC50 value of 6.3 μM
|
| T7157 |
XY1
|
1624117-53-8
|
98%
|
|
|
XY1 is a very close analogue of SGC707 (a potent, selective, and non-competitive inhibitor of PRMT3 with IC50 of 31 nM), It is intended to be used as a negative...
|
| T1868 |
JIB-04
|
199596-05-9
|
98.02%
|
|
|
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
|
| T40199 |
Tulmimetostat
|
2567686-02-4
|
98.04%
|
|
|
Tulmimetostat (CPI-0209) is an orally active EZH1/EZH2 inhibitor.Tulmimetostat has antitumor activity and is used in the study of ovarian cancer and advanced sol...
|
