| T67697 |
WDR5-47
|
1422389-91-0
|
98.08%
|
|
|
WDR5-47 is a potent small molecule to disturb the interaction of MLL1-WDR5 with IC50 value of 0.3μM.
|
| T16886 |
Sinefungin
|
58944-73-3
|
98.12%
|
|
|
Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multipl...
|
| T7305 |
JQEZ5
|
1913252-04-6
|
98.14%
|
|
|
JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).
|
| T12344L1 |
OTS186935 FA
|
|
98.16%
|
|
|
OTS186935 FA is a protein methyltransferase SUV39H2 inhibitor.OTS186935 FA inhibits tumor growth in MDA-MB-231 breast cancer cells and A549 lung cancer cells.
|
| T12428L |
PF-06726304
|
1616287-82-1
|
98.19%
|
|
|
PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH...
|
| T7194 |
CM-272
|
1846570-31-7
|
98.21%
|
|
|
CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor.
|
| T13780 |
MS1943
|
2225938-17-8
|
98.26%
|
|
|
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
|
| T6900 |
MS023
|
1831110-54-3
|
98.31%
|
|
|
MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, r...
|
| T13336 |
VTP50469
|
2169916-18-9
|
98.31%
|
|
|
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
|
| T60194 |
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide
|
2238820-26-1
|
98.33%
|
|
|
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(N-ethylcyclopropanecarboxamido)-4-methyl-4′-morpholino-[1,1′-biphenyl]-3-carboxamide is a potent and se...
|
| T6360 |
3-deazaneplanocin A HCl
|
120964-45-6
|
98.34%
|
|
|
3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.
|
| T8201 |
Gambogenic acid
|
173932-75-7
|
98.36%
|
|
|
Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.
|
| T9575 |
MRTX9768
|
2629314-68-5
|
98.48%
|
|
|
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors.
|
| TQ0100 |
AZ505
|
1035227-43-0
|
98.48%
|
|
|
AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
|
| T3624 |
A-366
|
1527503-11-2
|
98.53%
|
|
|
A-366 is a highly selective peptide-competitive histone methyltransferase G9a inhibitor with IC50s of 3.3 and 38 nM for G9a and GLP, respectively.It is more than...
|
| T23284 |
Ryuvidine
|
265312-55-8
|
98.6%
|
|
|
Ryuvidine is a dual inhibitor of KDM5A and SETD8, an inducer of the DNA damage response with potential anticancer activity, inhibition of H4K20 methylation, and ...
|
| T64043 |
EZH2-IN-13
|
1403255-41-3
|
98.68%
|
|
|
EZH2-IN-13 is a potent EZH2 inhibitor with potential anticancer activity.EZH2-IN-13 may be used to study diseases associated with EZH2 activity.
|
| T2097 |
C-7280948
|
587850-67-7
|
98.68%
|
|
|
C-7280948 is a PRMT1 inhibitor.
|
| T12943 |
SNDX-5613
|
2169919-21-3
|
98.7%
|
|
|
SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearra...
|
| T14841 |
BVT948
|
39674-97-0
|
98.70%
|
|
|
BVT948 is a protein tyrosine phosphatase (PTP) inhibitor. It can also inhibit several CYP450 isoforms and lysine methyltransferase SETD8 (KMT5A).
|
