IDO

Indoleamine-pyrrole 2,3-dioxygenase (IDO) is a heme-containing enzyme physiologically expressed in several tissues and cells, such as the small intestine, lungs, female genital tract or placenta.IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway. IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.

Cat. No.	製品名	CAS No.	Purity
T2647	IDO5L	914471-09-3	100%
T2647	IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
T11901	IDO1-IN-5	2166616-75-5	96.7%
T11901	IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T3548	Epacadostat	1204669-58-8	98.08%
T3548	Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
T9164	BMS-986242	1923844-48-7	98.25%
T9164	BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T10199	GNF-PF-3777	77603-42-0	99.47%
T10199	GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T11616	IDO-IN-13	2291164-02-6	99.57%
T11616	IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T11615	IDO-IN-12	1888341-29-4	99.61%
T11615	IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T20513	IDO1-IN-1	615-21-4	99.61%
T20513	IDO1-IN-1 (2 HzBTZ) is an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
T6407	β-Lapachone	4707-32-8	99.72%
T6407	β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.
T4532	Linrodostat	1923833-60-6	99.84%
T4532	Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T4307	PF-06840003	198474-05-4	99.89%
T4307	PF-06840003 (EOS200271) is a specific and oral active IDO-1 inhibitor.
T11628	IACS-8968 S-enantiomer	2239305-70-3	98%
T11628	IACS-8968 S-enantiomer is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11624	IDO1-IN-2	2346614-58-0	98%
T11624	IDO1-IN-2 is a potent and selective IDO1 inhibitor with IC50s of 81 nM, 59 nM (mouse), and 28 nM (rat), respectively. It has anti-cancer activity.
T11622	IDO-IN-9	1888378-12-8	98%
T11622	IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T11617	IDO-IN-3	2070018-30-1	98%
T11617	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11627	IACS-8968 R-enantiomer	2239305-67-8	98%
T11627	IACS-8968 R-enantiomer is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor (pIC50s: 6.43 for IDO and <5 for TDO).
T11614	IDO-IN-11	1888378-32-2	98%
T11614	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T11619	IDO-IN-5	1402837-79-9	98%
T11619	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11621	IDO-IN-8	1402837-77-7	98%
T11621	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T8214	Kushenol E	99119-72-9	98%
T8214	Kushenol E (Flemiphilippinin D) is a class of flavonoids isolated from Sophora flavescens. It is a non-competitive IDO1 inhibitor (IC50: 7.7 μM, Ki: 9.5 μM), has...