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Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase (TDO). IDO is an important part of the immune system and plays a part in natural defense against various pathogens. It is produced by the cells in response to inflammation and has an immunosuppressive function because of its ability to limit T-cell function and engage mechanisms of immune tolerance. Emerging evidence suggests that IDO becomes activated during tumor development, helping malignant cells escape eradication by the immune system. Expression of IDO has been described in a number of types of cancer, such as acute myeloid leukemia, ovarian cancer or colorectal cancer. IDO is part of the malignant transformation process and plays a key role in suppressing the anti-tumor immune response in the body, so inhibiting it could increase the effect of chemotherapy as well as other immunotherapeutic protocols.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T2647 IDO5L 914471-09-3 100%
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
T1847 Necrostatin-1 4311-88-0 100%
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
T3S1967 (S)-Indoximod 21339-55-9 95.39%
(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein ex...
T11901 IDO1-IN-5 2166616-75-5 96.7%
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
T4S0051 Coptisine sulfate 1198398-71-8 98%
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
T7181 IDO-IN-1 914638-30-5 98%
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
T3548 Epacadostat 1204669-58-8 98.08%
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
T9164 BMS-986242 1923844-48-7 98.25%
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
T5S0056 Coptisine chloride 6020-18-4 98.85%
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
T39476 NLG802 2071683-99-1 99.08%
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
T7660 IDO inhibitor 1 1204669-37-3 99.16%
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
T10199 GNF-PF-3777 77603-42-0 99.47%
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
T5S0802 Palmatine 3486-67-7 99.49%
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palma...
T6543 Indoximod 110117-83-4 99.5%
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenas...
T11616 IDO-IN-13 2291164-02-6 99.57%
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
T11615 IDO-IN-12 1888341-29-4 99.61%
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
T2718 Palmatine chloride 10605-02-4 99.64%
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
TQ0071 Navoximod 1402837-78-8 99.81%
Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
T4532 Linrodostat 1923833-60-6 99.84%
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
T1806 IDO-IN-7 1402836-58-1 99.87%
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
IDO5L
T2647
IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
Necrostatin-1
T1847
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin...
(S)-Indoximod
T3S1967
(S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein ex...
IDO1-IN-5
T11901
IDO1-IN-5 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
Coptisine sulfate
T4S0051
1. Coptisine sulfate has growth inhibitory activity against human cancer cell line in the NCI's anticancer drug screening program.
IDO-IN-1
T7181
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor( IC50 values of 59 and 12 nM for human IDO enzymatic activity and HeLa cell assays, respectively...
Epacadostat
T3548
Epacadostat (INCB 024360) is an oral-available inhibitor of indoleamine 2, 3-dioxygenase (IDO1), increasing the proliferation and activation of various immune ce...
BMS-986242
T9164
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
Coptisine chloride
T5S0056
1. Coptisine chloride (NSC-119754) can be absorbed across intestinal epithelial cells, and completely absorbed compounds.
NLG802
T39476
NLG802 is a prodrug of indoximod, an orally active indoleamine 2,3-dioxygenase (IDO) inhibitor.
IDO inhibitor 1
T7660
IDO inhibitor 1 is an potent inhibitor of indoleamine-2,3 dioxygenase (IDO) ( IC50 <100 nM).with potential immunomodulating and antineoplastic activities.
GNF-PF-3777
T10199
GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
Palmatine
T5S0802
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palma...
Indoximod
T6543
Indoximod (Indoximod (NLG-8189)) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenas...
IDO-IN-13
T11616
IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
IDO-IN-12
T11615
IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
Palmatine chloride
T2718
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
Navoximod
TQ0071
Navoximod (GDC-0919) (NLG- 919, GDC-0919) is a potent indoleamine-(2,3)-dioxygenase (IDO) pathway inhibitor (Ki/EC50: 7 nM/75 nM).
Linrodostat
T4532
Linrodostat (BMS-986205) is a selective indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor.
IDO-IN-7
T1806
IDO-IN-7 (NLG-919 analogue) is a potent IDO (indoleamine-(2, 3)-dioxygenase) pathway inhibitor.
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