| TP1897L1 |
JIP-1 (153-163) acetate(438567-88-5 free base)
|
TP1897L1
|
98%
|
|
|
JIP-1 (153-163) acetate is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1).
|
| T3200 |
DB07268
|
929007-72-7
|
98%
|
|
|
DB07268 is a potent and selective JNK1 inhibitor.
|
| T3079 |
GSK1838705A
|
1116235-97-2
|
98%
|
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
|
| T3895 |
Polyphyllin I
|
50773-41-6
|
98%
|
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| TN3967 |
Epieriocalyxin A
|
191545-24-1
|
98%
|
|
|
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth. It could be a potential drug for colon cancer therapy in the future.
|
| T9688 |
CC-90001
|
1403859-14-2
|
98%
|
|
|
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2.
|
| T5094 |
IRAK inhibitor 1
|
1042224-63-4
|
98%
|
|
|
IRAK inhibitor 1 is an effective IRAK-4 inhibitor (IC50: 216 nM), is poorly active against JNK-1 (IC50: 3.801 μM) and JNK-2 (IC50>10 μM).
|
| TN1236 |
3',4',7-Trihydroxyisoflavone
|
485-63-2
|
98%
|
|
|
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radic...
|
| TN1493 |
Chrysosplenol D
|
14965-20-9
|
98%
|
|
|
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.
|
| T2234 |
TCS JNK 5a
|
312917-14-9
|
98%
|
|
|
TCS JNK 5a (SC202671) is an effective, specific inhibitor of JNK3(pIC50= 6.7), JNK2(pIC50=6.5).
|
| TN1403 |
Arjunolic acid
|
465-00-9
|
98%
|
|
|
Arjunolic acid has antioxidant, anti-inflammatory, antinociceptive and anticholinesterasic (AChE and BuChE) activities, it may as promising targets for the devel...
|
| T8661 |
AS601245.2TFA (345987-15-7 free base)
|
345987-16-8
|
98%
|
|
|
AS601245.2TFA (345987-15-7 free base) (AS601245.2TFA) is a cell-permeable Inhibitor of JNK (IC50s of 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectivel...
|
| T6150 |
TAK-715
|
303162-79-0
|
98%
|
|
|
TAK-715 is a p38 MAPK inhibitor for p38α.
|
| T8477 |
IQ-3
|
312538-03-7
|
|
|
|
IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in ...
|
| TN1918 |
Medicarpin
|
32383-76-9
|
|
|
|
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of pea...
|
| TN1448 |
(-)-Bornyl acetate
|
5655-61-8
|
|
|
|
(-)-Bornyl acetate (L-(-)-Bornyl acetate) is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate isolates from hyssop oil and possesses antifungal...
|
| T7190 |
Actein
|
18642-44-9
|
|
|
|
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblast...
|
| T3S0209 |
Vincristine
|
57-22-7
|
100%
|
|
|
Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-...
|
| T6784 |
BI-78D3
|
883065-90-5
|
100%
|
|
|
BI-78D3, a competitive JNK inhibitor. IC50 of BI-78D3 is 280 nM that displays > 100 fold selectivity over p38α, and have no activity at mTOR and PI-3K.
|
