LIM Kinase

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several upstream signalling pathways, principally acting downstream of Rho GTPases to influence the architecture of the actin cytoskeleton by regulating the activity of the cofilin family proteins cofilin1, cofilin2 and destrin. Although the LIM kinases are very homologous, particularly when comparing kinase domains, there is emerging evidence that each may be subject to different regulatory pathways and may contribute to both distinct and overlapping cellular and developmental functions.

Cat. No.	製品名	CAS No.	Purity
T36680	SM1-71	2088179-99-9	98%
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
T24410	LIMK-IN-22j	1116571-01-7	98%
LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.
T7128	TH-257	2244678-29-1	98%
TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
T3960	T56-LIMKi	924473-59-6	98.61%
T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.
T12609	R-10015	2097938-51-5	98.97%
R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 n...
T4600	BMS-3	1338247-30-5	99.31%
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
T4598	BMS-5	1338247-35-0	99.88%
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
T15798	LX7101	1192189-69-7	98%
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T15809	LY2812223	1311385-20-2	98%
LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, res...

Cat. No.

製品名

CAS No.

Purity

Chemical Structure

T36680

SM1-71

2088179-99-9

98%

SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...

T24410

LIMK-IN-22j

1116571-01-7

98%

LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.

T7128

TH-257

2244678-29-1

98%

TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

T3960

T56-LIMKi

924473-59-6

98.61%

T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.

T12609

R-10015

2097938-51-5

98.97%

R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 n...

T4600

BMS-3

1338247-30-5

99.31%

BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.

T4598

BMS-5

1338247-35-0

99.88%

BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.

T15798

LX7101

1192189-69-7

98%

LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).

T15809

LY2812223

1311385-20-2

98%

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, res...