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LPL Receptor

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eight LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg" (an acronym for endothelial differentiation gene).
Cat. No. 製品名 CAS No. Purity Chemical Structure
T9464 CYM50358 1314212-39-9 98%
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 ...
T6085 PF-543 1415562-82-1 98%
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T2000 AM095 1345614-59-6 98%
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
T12086 Mocravimod hydrochloride 509088-69-1 98%
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
T76828 Sonepcizumab 1031360-18-5 98%
Sonepcizumab
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell...
T21500 Sphingosine-1-phosphate 26993-30-6 98%
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
T0307 Tyloxapol 25301-02-4 98%
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
T15629 JTE-013 383150-41-2
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T7393 ONO-7300243 638132-34-0
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
T2026 CYM5442 1094042-01-9 96.65%
CYM5442 is an S1P agonist, targeting to Sphingosine.
T3961 CYM-5541 945128-26-7 97.34%
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
T6347 Ki16198 355025-13-7 97.6%
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
T7360 GSK2018682 1034688-30-6 97.78%
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T6403 Siponimod 1230487-00-9 97.79%
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
T9199 GLPG2938 2130996-00-6 98.1%
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
T6108 Ki16425 355025-24-0 98.54%
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
T61112 SLF1081851 2763730-97-6 98.57%
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
T4016 BMS-986020 1257213-50-5 98.61%
BMS-986020 (AM152) is a selective antagonist of LPA1.
T22703 CYM-5520 1449747-00-5 98.72%
CYM-5520 is a noncompetitive allosteric agonist of S1P2
T28169 NIBR-0213 1233332-14-3 98.87%
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
CYM50358
T9464
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 ...
PF-543
T6085
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
AM095
T2000
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively.
Mocravimod hydrochloride
T12086
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
Sonepcizumab
T76828
Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell...
Sphingosine-1-phosphate
T21500
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
Tyloxapol
T0307
Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant.
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
ONO-7300243
T7393
ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM).
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
CYM-5541
T3961
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
Ki16198
T6347
Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ...
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
Siponimod
T6403
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
GLPG2938
T9199
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
Ki16425
T6108
Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively.
SLF1081851
T61112
SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM.
BMS-986020
T4016
BMS-986020 (AM152) is a selective antagonist of LPA1.
CYM-5520
T22703
CYM-5520 is a noncompetitive allosteric agonist of S1P2
NIBR-0213
T28169
NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis.
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