Cat. No. | 製品名 | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T9464 | CYM50358 | 1314212-39-9 | 98% |
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N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 ... | ||||
T6085 | PF-543 | 1415562-82-1 | 98% |
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PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. | ||||
T2000 | AM095 | 1345614-59-6 | 98% |
|
AM095 is a potent LPA1 receptor antagonist with IC50 values of 0.98 and 0.73 μM for recombinant human or mouse LPA1 respectively. | ||||
T12086 | Mocravimod hydrochloride | 509088-69-1 | 98% |
|
Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1). | ||||
T76828 | Sonepcizumab | 1031360-18-5 | 98% |
Sonepcizumab
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Sonepcizumab (LT 1009) is a fully humanized monoclonal antibody against S1P. Sonepcizumab has anti-cancer activity and can be used to study metastatic renal cell... | ||||
T21500 | Sphingosine-1-phosphate | 26993-30-6 | 98% |
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Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ... | ||||
T0307 | Tyloxapol | 25301-02-4 | 98% |
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Tyloxapol (Triton WR1339) is a non-ionic liquid polymer used as a surfactant. | ||||
T15629 | JTE-013 | 383150-41-2 |
|
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JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n... | ||||
T7393 | ONO-7300243 | 638132-34-0 |
|
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ONO-7300243 is an antagonist of lysophosphatidic acid receptor 1 (LPA1; IC50 : 0.16 µM). | ||||
T2026 | CYM5442 | 1094042-01-9 | 96.65% |
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CYM5442 is an S1P agonist, targeting to Sphingosine. | ||||
T3961 | CYM-5541 | 945128-26-7 | 97.34% |
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CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist. | ||||
T6347 | Ki16198 | 355025-13-7 | 97.6% |
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Ki16198 is the methyl ester of Ki16425, which is a LPA antagonist and inhibits LPA1- and LPA3-induced inositol phosphate production with Ki of 0.34 μM and 0.93 μ... | ||||
T7360 | GSK2018682 | 1034688-30-6 | 97.78% |
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively). | ||||
T6403 | Siponimod | 1230487-00-9 | 97.79% |
|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T... | ||||
T9199 | GLPG2938 | 2130996-00-6 | 98.1% |
|
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s... | ||||
T6108 | Ki16425 | 355025-24-0 | 98.54% |
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Ki16425 (Debio 0719) is a competitive, potent and reversible antagonist to LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, respectively. | ||||
T61112 | SLF1081851 | 2763730-97-6 | 98.57% |
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SLF1081851 is a Spns2 inhibitor. SLF1081851 inhibits S1P release with IC50 of 1.93 μM. | ||||
T4016 | BMS-986020 | 1257213-50-5 | 98.61% |
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BMS-986020 (AM152) is a selective antagonist of LPA1. | ||||
T22703 | CYM-5520 | 1449747-00-5 | 98.72% |
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CYM-5520 is a noncompetitive allosteric agonist of S1P2 | ||||
T28169 | NIBR-0213 | 1233332-14-3 | 98.87% |
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NIBR-0213, a potent and selective S1P(1) antagonist, has efficacy in experimental autoimmune encephalomyelitis. |