| T6057 |
URMC-099
|
1229582-33-5
|
98%
|
|
|
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
|
| T39972 |
EB-42486
|
2390475-81-5
|
98%
|
|
|
EB-42486 is an effective and highly selective inhibitor of G2019S-LRRK2 with an IC50 < 0.2 nM.
|
| T5428 |
BIX 02565
|
1311367-27-7
|
98%
|
|
|
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
|
| T7196 |
HG-10-102-01
|
1351758-81-0
|
98%
|
|
|
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
|
| T7155 |
JH-II-127
|
1700693-08-8
|
98%
|
|
|
JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, re...
|
| T1770 |
GNE-9605
|
1536200-31-3
|
98%
|
|
|
GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).
|
| T7729 |
PF-06454589
|
1527473-30-8
|
96.29%
|
|
|
PF-06454589 is a potent inhibitor of LRRK2.
|
| T1945 |
GNE-7915
|
1351761-44-8
|
98%
|
|
|
GNE-7915 is a highly potent, selective and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) inhibitor.
|
| T3053 |
CZC-25146
|
1191911-26-8
|
98.2%
|
|
|
CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat ki...
|
| T39202 |
CZC-54252 hydrochloride
|
1784253-05-9
|
98.21%
|
|
|
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuropr...
|
| T2246 |
LRRK2-IN-1
|
1234480-84-2
|
98.44%
|
|
|
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor.
|
| T5139 |
CZC-25146 hydrochloride
|
1330003-04-7
|
99.06%
|
|
|
CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.
|
| T16115 |
MLi-2
|
1627091-47-7
|
99.33%
|
|
|
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a ...
|
| T2022 |
CZC-54252
|
1191911-27-9
|
99.39%
|
|
|
CZC-54252 is a potent inhibitor of LRRK2.
|
| T6176 |
IKK 16
|
873225-46-8
|
99.61%
|
|
|
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
|
| T2050 |
PF-06447475
|
1527473-33-1
|
99.62%
|
|
|
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
|
| T11878 |
LRRK2 inhibitor 1
|
1802525-61-6
|
99.73%
|
|
|
LRRK2 inhibitor 1 is a selective and potent LRRK2 inhibitor with an IC50 of 13 nM.LRRK2 inhibitor 1 inhibits DCLK1 kinase with an IC50 value of 2.61 nM.
|
| T16512 |
PFE-360
|
1527475-61-1
|
99.73%
|
|
|
PFE-360 (PF-06685360) is a potent and selective inhibitor of LRRK2 kinase (IC50: 2.3 nM in vivo).
|
| T2240 |
GSK2578215A
|
1285515-21-0
|
99.81%
|
|
|
GSK2578215A is a potent and selective LRRK2 kinase inhibitor.
|
| T6031 |
GNE0877
|
1374828-69-9
|
99.96%
|
|
|
GNE0877 (GNE 0877) is a highly effective and specific leucine-rich repeat kinase 2 (LRRK2) inhibitor (Ki: 0.7 nM).
|
