LTR

LTR retrotransposons are class I transposable element characterized by the presence of Long Terminal Repeats (LTRs) directly flanking an internal coding region. As retrotransposons, they mobilize through reverse-transcription of their mRNA and integration of the newly created cDNA into another location. Their mechanism of retrotransposition is shared with retroviruses, with the difference that most LTR-retrotransposons do not form infectious particles that leave the cells and therefore only replicate inside their genome of origin.

カタログ番号	製品名
T17191	Bunaprolast	Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
T15002	CP-105696	CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
TN5164	Trans-Hinokiresinol	Hinokiresinol is a novel inhibitor of LTB4 binding to the human neutrophils, it has antiallergic effect, it inhibits IgE-induced mouse passive cutaneous anaphyla...
T15813	LY309887	LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM). It also has antitumor activity.
T13295	Veliflapon	Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and ...
TN3983	Ergosta-7,22-dien-3-one	Ergosta-7,22-dien-3-one shows pro-inflammatory property, it can stimulate nitric oxide production, induce the expression of genes, and induce the production of T...
T14210	Amelubant	Amelubant (BIIL 284) is a prodrug of active metabolites BIIL 260 and BIIL 315. Anti-inflammatory activity[1]. Amelubant (BIIL 284) is a potent, oral and long act...
T16395	ONO4057	ONO4057 is an antagonist of the Leukotriene B4 receptor (IC50: 0.7±0.3 μM).
T15182	DW-1350	DW-1350 is an antagonist of LTB4 receptor.
T10208	A-69412	A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other in...
T11487	Fiboflapon	Fiboflapon is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition...
T11487L	Fiboflapon sodium	Fiboflapon sodium (GSK2190915) is an orally bioavailable 5-lipoxygenase-activating protein (FLAP) inhibitor with a potency of 2.9 nM in FLAP binding, an IC50 of ...
T10960	Darbufelone	Darbufelone is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGH...
T9878	Croconazole	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
T21504	γ-Linolenic Acid methyl ester	γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
T1677	Montelukast	Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
T3738	3-(4-Hydroxyphenyl)-1-propanol	3-(4-hydroxyphenyl)-1-propanol is a member of the class of compounds known as 1-hydroxy-2-unsubstituted benzenoids.
T3148	MK-571 sodium	MK-571 is a selective, orally active antagonist of the CysLT1 receptor. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the...
T22358	Etalocib	Etalocib is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotr...
T4192	Hnps-PLA Inhibitor	Hnps-PLA Inhibitor is an inhibitor of human nonpancreatic secretory Phospholipase A (hnps-PLA).
T3715	Acebilustat	Acebilustat (ZK322) is an effective and specific leukotriene B4 hydrolase inhibitor.
T7841	MK 571	MK 571 is an orally active antagonist of CysLT1 receptor .
T1257	Bestatin	Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Ubenimex is a microbial metabolite and dipeptide with potential...
T10917	LTB4-IN-1	LTB4-IN-1 with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).
T4114	Diffractaic Acid	Diffractaic Acid can inhibit LTB4 biosynthesis in A-23187-stimulated bovine PMNL cells with activity value of 8 μM.
T0694	Pranlukast	Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. It antagonizes or reduces bronchospasm caused, principally in asthmatics, by an allergic reaction to...
T1677L	Montelukast sodium	Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...