T9687 |
MAGL-IN-4
|
2135785-20-3
|
98%
|
|
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
|
T5353 |
ABX-1431
|
1446817-84-0
|
98%
|
|
ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
|
T4052 |
KML29
|
1380424-42-9
|
98%
|
|
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It ha...
|
T11199 |
Endothelial lipase inhibitor-1
|
1466427-02-0
|
97.38%
|
|
Endothelial lipase inhibitor-1 is a potent endothelial lipase inhibitor with an IC50 of 49 nM.
|
T6554 |
JZL 184
|
1101854-58-3
|
97.6%
|
|
JZL 184 is a potent and selective inhibitor of MAGL with IC50 of 8 nM and 4 μM for inhibition of MAGL and FAAH in mouse brain membranes respectively.
|
T5815 |
MJN110
|
1438416-21-7
|
98%
|
|
MJN110 (Cravatt Reagent) is a potent and selective MAGL inhibitor. Cravatt Reagent inhibits MAGL (IC50 = 9.1 nM). MJN110(Cravatt Reagent) Produces Opioid-Sparing...
|
T5737 |
Euphol
|
514-47-6
|
98%
|
|
Euphol, an alcohol tetracyclic triterpene, has a wide range of pharmacological properties and is considered to have anti-inflammatory action.
|
T28165 |
NF-1819
|
1881244-28-5
|
98.21%
|
|
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhi...
|
T17260 |
WWL70
|
947669-91-2
|
98.25%
|
|
WWL70 is a selective alpha/beta hydrolase domain 6 inhibitors (IC50: 70 nM).
|
T41160 |
Lalistat 2
|
1234569-09-5
|
98.30%
|
|
Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein...
|
T15635 |
JZP-430
|
1672691-74-5
|
98.31%
|
|
JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty...
|
T15632 |
JW 642
|
1416133-89-5
|
99.13%
|
|
JW 642 is an effective inhibitor of monoacylglycerol lipase (MAGL) (IC50: 7.6, 14, and 3.7 nM for inhibition of MAGL in mouse, rat, and human brain membranes, r...
|
T15614 |
JJKK 048
|
1515855-97-6
|
99.22%
|
|
JJKK 048 is a potent and selective MAGL inhibitor.
|
T1846 |
Y-320
|
288250-47-5
|
99.23%
|
|
Y-320 is a new phenylpyrazoleanilide immunomodulator.
|
T27703 |
JZP-361
|
1680193-80-9
|
99.41%
|
|
JZP-361 is a specific MAGL inhibitor with IC50s of 46 nM, 7.24 μM, and 1.79 μM for human recombinant MAGL, human recombinant FAAH, and human hABHD6. JZP-361 disp...
|
T73499 |
NG-497
|
2598242-66-9
|
99.56%
|
|
NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain ...
|
T3591 |
URB602
|
565460-15-3
|
99.64%
|
|
URB602 is a specific monoacylglycerol lipase (MGL) inhibitor, which inhibits rat brain MGL (IC50: 28±4 μM) through a noncompetitive mechanism.
|
T2966 |
Beta-Sitosterol
|
83-46-5
|
99.68%
|
|
Beta-Sitosterol (SKF 14463) has recently been shown to induce G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways. Be...
|
T9374 |
AA38-3
|
65815-76-1
|
99.70%
|
|
AA38-3 (1-Piperidinecarboxylic acid, 4-nitrophenyl ester) inhibites three SHs (ABHD6, ABHD11, and FAAH)
|
T2249 |
XEN445
|
1515856-92-4
|
99.75%
|
|
XEN445, a potent and selective endothelial lipase(EL) inhibitor (IC50=0.237 uM), exhibitis good ADME and PK properties.
|