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Liver X Receptor

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis. LXRs were earlier classified as orphan nuclear receptors, however, upon discovery of endogenous oxysterols as ligands, they were subsequently deorphanized.Two isoforms of LXR have been identified and are referred to as LXRα and LXRβ.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T10086 24-Hydroxycholesterol 30271-38-6 98%
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcripti...
T68316 GAC0003A4 929492-71-7 98%
GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits t...
T3970 BMS-779788 918348-67-1 98%
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
T16792 Rovazolac 1454288-88-0 98%
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis.
T16930 SR9238 1416153-62-2 98%
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
T1801 SR9243 1613028-81-1 98%
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
TN2359 Iristectorigenin B 86849-77-6 98%
Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigen...
T1783 LXR-623 875787-07-8 97.91%
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
TN1055 Licochalcone E 864232-34-8 98.09%
Licochalcone E is a potential LXRβ agonist.
T2810 (20S)-Protopanaxatriol 34080-08-5 98.12%
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid re...
T2768 Saikosaponin A 20736-09-8 98.76%
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
T15427 GSK2033 1221277-90-2 99.05%
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
TQ0274 27-Hydroxycholesterol 20380-11-4 99.31%
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
T5178 AZ876 898800-26-5 99.41%
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T6690 T0901317 293754-55-9 99.43%
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
T7768 RGX-104 610318-54-2 99.46%
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
T27478 GSK3987 264206-85-1 99.48%
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
T5128 RGX-104 hydrochloride 610318-03-1 99.49%
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity ...
T5743 Gymnemagenin 22467-07-8 99.67%
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
T63896 BE1218 2893967-40-1 99.7%
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.
24-Hydroxycholesterol
T10086
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcripti...
GAC0003A4
T68316
GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits t...
BMS-779788
T3970
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
Rovazolac
T16792
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis.
SR9238
T16930
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
SR9243
T1801
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
Iristectorigenin B
TN2359
Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigen...
LXR-623
T1783
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
Licochalcone E
TN1055
Licochalcone E is a potential LXRβ agonist.
(20S)-Protopanaxatriol
T2810
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid re...
Saikosaponin A
T2768
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
GSK2033
T15427
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
27-Hydroxycholesterol
TQ0274
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
AZ876
T5178
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
T0901317
T6690
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
RGX-104
T7768
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
GSK3987
T27478
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
RGX-104 hydrochloride
T5128
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity ...
Gymnemagenin
T5743
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
BE1218
T63896
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.
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