T10086 |
24-Hydroxycholesterol
|
30271-38-6
|
98%
|
|
24-Hydroxycholesterol (Cholest-5-ene-3beta,24-diol) is an oxysterol compound that is an activator of the n-methyl-d-aspartate receptor (NMDA) and the transcripti...
|
T68316 |
GAC0003A4
|
929492-71-7
|
98%
|
|
GAC0003A4 is a potent LXR inverse agonist with antitumor activity that inhibits the transcription of LXR proteins.GAC0003A4 degrades LXRβ proteins and inhibits t...
|
T3970 |
BMS-779788
|
918348-67-1
|
98%
|
|
BMS-779788 (XL-652) is an LXRα/β partial agonist (IC50: 68/14 nM).
|
T16792 |
Rovazolac
|
1454288-88-0
|
98%
|
|
Rovazolac (ALX-101) is a liver x receptor (LXR) modulator used in the study of immune system disorders and atopic dermatitis.
|
T16930 |
SR9238
|
1416153-62-2
|
98%
|
|
SR9238 is a synthetic agonist of liver X receptor inverse (IC50s: 214 nM and 43 nM for LXRα and LXRβ, respectively).
|
T1801 |
SR9243
|
1613028-81-1
|
98%
|
|
SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
|
TN2359 |
Iristectorigenin B
|
86849-77-6
|
98%
|
|
Iristectorigenin B (Iristectrigenin B) is a potent hepatic X-receptor (LXR) modulator, a small molecule compound isolated from Belamcanda chinensis.Iristectrigen...
|
T1783 |
LXR-623
|
875787-07-8
|
97.91%
|
|
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR.
|
TN1055 |
Licochalcone E
|
864232-34-8
|
98.09%
|
|
Licochalcone E is a potential LXRβ agonist.
|
T2810 |
(20S)-Protopanaxatriol
|
34080-08-5
|
98.12%
|
|
(20S)-Protopanaxatriol (g-PPT)(g-PPT), a metabolite of ginsenoside, could regulate endothelial cell functions through the estrogen receptor and glucocorticoid re...
|
T2768 |
Saikosaponin A
|
20736-09-8
|
98.76%
|
|
Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-b...
|
T15427 |
GSK2033
|
1221277-90-2
|
99.05%
|
|
GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).
|
TQ0274 |
27-Hydroxycholesterol
|
20380-11-4
|
99.31%
|
|
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) is a selective modulator of estrogen receptor and an agonist of the liver X receptor.
|
T5178 |
AZ876
|
898800-26-5
|
99.41%
|
|
AZ876 is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
|
T6690 |
T0901317
|
293754-55-9
|
99.43%
|
|
T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).
|
T7768 |
RGX-104
|
610318-54-2
|
99.46%
|
|
RGX-104 (RGX-104 free Acid) free Acid is an agonist of potent liver-X nuclear hormone receptor (LXR)
|
T27478 |
GSK3987
|
264206-85-1
|
99.48%
|
|
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
|
T5128 |
RGX-104 hydrochloride
|
610318-03-1
|
99.49%
|
|
RGX-104 hydrochloride (SB742881) is a liver X receptor (LXR) agonist with potential immunomodulating and antineoplastic activities. It modulates innate immunity ...
|
T5743 |
Gymnemagenin
|
22467-07-8
|
99.67%
|
|
Gymnemagenin is a potent and selective antagonist for the β isoform of LXR, it has antihyperglycemic activity.
|
T63896 |
BE1218
|
2893967-40-1
|
99.7%
|
|
BE1218 is a liver X receptor (LXR) inverse agonist active on LXRα and LXRβ with an IC50 of 9 nM and 7 nM, respectively.
|