MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.

Cat. No.	製品名	CAS No.	Purity
T16432	Pan-RAS-IN-1	1835283-94-7	98%
T16432	Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
TN1660	Ganoderic acid C1	95311-97-0	98%
TN1660	Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T40350	HPK1-IN-4	2739844-28-9	98%
T40350	HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T3672	Nomilin	1063-77-0	98%
T3672	Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
T12979	BI-3406	2230836-55-0	98%
T12979	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T5S1895	Norisoboldine	23599-69-1	98%
T5S1895	1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
T3350	Selonsertib	1448428-04-3	98%
T3350	Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibroti...
TN1711	Gossypetin	489-35-0	98%
TN1711	Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
T7283	Sodium lauroyl-α-hydroxyethyl sulfonate	T7283	98%
T7283	Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T8843	APS6-45	2188236-41-9	98%
T8843	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
TN4114	Gardenin A	21187-73-5	98%
TN4114	Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T9880	ZINC05007751	591239-68-8	98%
T9880	ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
T3101	NQDI-1	175026-96-7	98%
T3101	NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T60012	HS-243	848249-10-5	98%
T60012	HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T5643	NG25	1315355-93-1	98%
T5643	NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
T8911	Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate	517870-17-6	98%
T8911	methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
T62209	HS-276	2767422-72-8	98%
T62209	HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
T9034	MK2-IN-3	724711-21-1	98%
T9034	MK2-IN-3 is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatme...
T26193	SKLB-163	1255099-06-9	98%
T26193	SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...