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MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T16432 Pan-RAS-IN-1 1835283-94-7 98%
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
TN1660 Ganoderic acid C1 95311-97-0 98%
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
T40350 HPK1-IN-4 2739844-28-9 98%
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
T14072 A-443654 552325-16-3 98%
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T3672 Nomilin 1063-77-0 98%
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
T12979 BI-3406 2230836-55-0 98%
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T5S1895 Norisoboldine 23599-69-1 98%
1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
T3350 Selonsertib 1448428-04-3 98%
Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibroti...
TN1711 Gossypetin 489-35-0 98%
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
T7283 Sodium lauroyl-α-hydroxyethyl sulfonate T7283 98%
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
T8843 APS6-45 2188236-41-9 98%
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
TN4114 Gardenin A 21187-73-5 98%
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
T9880 ZINC05007751 591239-68-8 98%
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
T3101 NQDI-1 175026-96-7 98%
NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
T60012 HS-243 848249-10-5 98%
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
T5643 NG25 1315355-93-1 98%
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
T8911 Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate 517870-17-6 98%
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
T62209 HS-276 2767422-72-8 98%
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
T9034 MK2-IN-3 724711-21-1 98%
MK2-IN-3 is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatme...
T26193 SKLB-163 1255099-06-9 98%
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
Pan-RAS-IN-1
T16432
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
Ganoderic acid C1
TN1660
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
HPK1-IN-4
T40350
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
Nomilin
T3672
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
BI-3406
T12979
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
Norisoboldine
T5S1895
1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
Selonsertib
T3350
Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibroti...
Gossypetin
TN1711
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
sodium lauroyl-α-hydroxyethyl sulfonate
T7283
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
APS6-45
T8843
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
Gardenin A
TN4114
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
ZINC05007751
T9880
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
NQDI-1
T3101
NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
HS-243
T60012
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
NG25
T5643
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
T8911
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
HS-276
T62209
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
MK2-IN-3
T9034
MK2-IN-3 is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatme...
SKLB-163
T26193
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
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