T16432 |
Pan-RAS-IN-1
|
1835283-94-7
|
98%
|
|
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
|
TN1660 |
Ganoderic acid C1
|
95311-97-0
|
98%
|
|
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic ac...
|
T40350 |
HPK1-IN-4
|
2739844-28-9
|
98%
|
|
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
|
T14072 |
A-443654
|
552325-16-3
|
98%
|
|
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
T3672 |
Nomilin
|
1063-77-0
|
98%
|
|
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
|
T12979 |
BI-3406
|
2230836-55-0
|
98%
|
|
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
|
T5S1895 |
Norisoboldine
|
23599-69-1
|
98%
|
|
1. Norisoboldine might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as well as regulating the...
|
T3350 |
Selonsertib
|
1448428-04-3
|
98%
|
|
Selonsertib is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibroti...
|
TN1711 |
Gossypetin
|
489-35-0
|
98%
|
|
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
|
T7283 |
Sodium lauroyl-α-hydroxyethyl sulfonate
|
T7283
|
98%
|
|
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
|
T8843 |
APS6-45
|
2188236-41-9
|
98%
|
|
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
|
TN4114 |
Gardenin A
|
21187-73-5
|
98%
|
|
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
|
T9880 |
ZINC05007751
|
591239-68-8
|
98%
|
|
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
|
T3101 |
NQDI-1
|
175026-96-7
|
98%
|
|
NQDI-1 is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
|
T60012 |
HS-243
|
848249-10-5
|
98%
|
|
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
|
T5643 |
NG25
|
1315355-93-1
|
98%
|
|
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
|
T8911 |
Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
|
517870-17-6
|
98%
|
|
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
|
T62209 |
HS-276
|
2767422-72-8
|
98%
|
|
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
|
T9034 |
MK2-IN-3
|
724711-21-1
|
98%
|
|
MK2-IN-3 is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatme...
|
T26193 |
SKLB-163
|
1255099-06-9
|
98%
|
|
SKLB-163 is an anticancer agent that acts by downregulating RhoGDI, decreasing phosphorylated Akt and p44/42 MAPK, and activating JNK-1 signaling pathway and cas...
|