| T28141 |
Nek2-IN-5
|
1507367-00-1
|
98%
|
|
|
Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).
|
| T16432 |
Pan-RAS-IN-1
|
1835283-94-7
|
98%
|
|
|
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
|
| T21547 |
PAF (C16)
|
74389-68-7
|
98%
|
|
|
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholi...
|
| TN1711 |
Gossypetin
|
489-35-0
|
98%
|
|
|
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3/6-p38 signal...
|
| T35593 |
Semapimod tetrahydrochloride
|
164301-51-3
|
98%
|
|
|
Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) is a synthetic ornithine mitogen-activated protein kinase blocker and pro-inflammatory cytokine produ...
|
| TN1236 |
3',4',7-Trihydroxyisoflavone
|
485-63-2
|
98%
|
|
|
3',4',7-Trihydroxyisoflavone is a soy isoflavone soy glycoside derivative and Cot (Tpl2/MAP3K8) and MKK4 inhibitor with anticancer, antiangiogenic and free radic...
|
| T40577 |
TAK1-IN-3
|
494772-87-1
|
98%
|
|
|
TAK1-IN-3 is a novel ATP-competitive TAK1 inhibitor for the study of cancer.
|
| T14072 |
A-443654
|
552325-16-3
|
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
| T3672 |
Nomilin
|
1063-77-0
|
|
|
|
Nomilin is naturally occurring triterpenoids, have immunomodulatory activity.
|
| T7283 |
Sodium lauroyl-α-hydroxyethyl sulfonate
|
T7283
|
|
|
|
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
|
| T12979 |
BI-3406
|
2230836-55-0
|
100%
|
|
|
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
|
| T8843 |
APS6-45
|
2188236-41-9
|
100%
|
|
|
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
|
| TN4114 |
Gardenin A
|
21187-73-5
|
95.15%
|
|
|
Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
|
| T36680 |
SM1-71
|
2088179-99-9
|
96%
|
|
|
SM1-71 is a potent multi-targeted acrylamide-modified TAK1 inhibitor that inhibits MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3,...
|
| T63119 |
NF-κB/MAPK-IN-1
|
2413940-56-2
|
97.03%
|
|
|
NF-κB/MAPK-IN-1 is a potent dual inhibitor of the NF-κB and MAPK pathways with potential anti-inflammatory activity, inhibition of NO production, and inhibition ...
|
| T9880 |
ZINC05007751
|
591239-68-8
|
97.12%
|
|
|
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant acti...
|
| T3101 |
NQDI-1
|
175026-96-7
|
97.19%
|
|
|
NQDI-1 (NQDI 1) is a selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1, MAP3K5) (IC50/Ki: 3 μM/500 nM).
|
| T40350 |
HPK1-IN-4
|
2739844-28-9
|
97.2%
|
|
|
HPK1-IN-4 is an HPK1 (MAPK41) inhibitor with an IC 50 of 0.061 nM. HPK1-IN-4 is often used as a preclinical immunotherapy tool compound.
|
| T60012 |
HS-243
|
848249-10-5
|
97.34%
|
|
|
HS-243 is an inhibitor of IRAK-4 and IRAK-1 with IC50s of 20 and 24 nM. HS-243 shows anti-inflammatory and anticancer activity.
|
| T5643 |
NG25
|
1315355-93-1
|
97.59%
|
|
|
NG25 is a potent dual TAK1 and MAP4K2 inhibitor, with IC50s of 149 nM and 21.7 nM, respectively.
|
