| T8911 |
Methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate
|
517870-17-6
|
97.95%
|
|
|
methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.
|
| T62209 |
HS-276
|
2767422-72-8
|
98.07%
|
|
|
HS-276 is a highly selective, orally active inhibitor of TAK1 (Ki: 2.5 nM). HS-276 significantly inhibits TAK1 (IC50: 8.25 nM), CLK2 (IC50: 29 nM), GCK (IC50: 22...
|
| T9034 |
MK2-IN-3
|
724711-21-1
|
98.14%
|
|
|
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be ...
|
| T10865L |
Cot inhibitor-1 hydrochloride
|
T10865L
|
98.26%
|
|
|
Cot inhibitor-1 hydrochloride is an inhibitor of tumor progression loci-2 kinase (IC50 = 28 nM) and inhibits the production of TNF-α in human whole blood (IC50 =...
|
| T26193 |
SKLB-163
|
1255099-06-9
|
98.31%
|
|
|
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
|
| T11961 |
MBM-55S
|
2083624-07-9
|
98.38%
|
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
| T12237 |
NMS-P715
|
1202055-32-0
|
98.41%
|
|
|
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
|
| T4264 |
Takinib
|
1111556-37-6
|
98.47%
|
|
|
Takinib (EDHS-206) is a specific and effective TAK1 inhibitor(IC50= 9.5 nM).
|
| T5S1895 |
Norisoboldine
|
23599-69-1
|
98.64%
|
|
|
1. Norisoboldine ((+)-Laurelliptine) might be a potential therapeutic agent for rheumatoid arthritis, and it functions through protecting joint destruction as we...
|
| T3707 |
GNE-3511
|
1496581-76-0
|
98.64%
|
|
|
GNE-3511 is a potent and selective dual leucine zipper kinase inhibitors.
|
| T6760 |
APS-2-79 hydrochloride
|
2002381-31-7
|
98.64%
|
|
|
APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization as well as the co...
|
| T11438 |
GNE-1858
|
2680616-96-8
|
98.70%
|
|
|
GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutan...
|
| T3836 |
Eudesmin
|
526-06-7
|
98.86%
|
|
|
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...
|
| T10866 |
Cot inhibitor-2
|
915363-56-3
|
98.87%
|
|
|
Cot inhibitor-2 is a cot (Tpl2/MAP3K8) inhibitor (IC50: 1.6 nM) with potency, selectivity and oral activity. cot inhibitor-2 inhibits LPS-stimulated TNF-α produc...
|
| T60657 |
(R)-STU104
|
2767124-77-4
|
98.91%
|
|
|
(R)-STU104 is a novel TAK1-MKK3 protein-protein interaction (PPI) inhibitor that inhibits TNF-α and suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signalling pathwa...
|
| TN2081 |
Maohuoside A
|
128988-55-6
|
98.91%
|
|
|
Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.
|
| TN1445 |
Bisabolangelone
|
30557-81-4
|
98.91%
|
|
|
Bisabolangelone has anti-tumor, anti-inflammatory, anti-microbial, and antioxidant activities, it inhibits dendritic cell functions by blocking MAPK and NF-κB si...
|
| T3350 |
Selonsertib
|
1448428-04-3
|
98.97%
|
|
|
Selonsertib (GS-4997) is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and an...
|
| T16501 |
PF-3644022
|
1276121-88-0
|
99.12%
|
|
|
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production...
|
| T12058 |
MK2-IN-3 hydrate
|
1186648-22-5
|
99.14%
|
|
|
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM)
|
