MTH1

2-hydroxy-dATP diphosphatase , also known as oxidized purine nucleoside triphosphatase, or (2'-deoxy) ribonucleoside 5'-triphosphate pyrophosphohydrolase, or Nudix hydrolase 1 (NUDT1), or MutT homolog 1 (MTH1), or 7,8-dihydro-8-oxoguanine triphosphatase) is an enzyme that in humans is encoded by the NUDT1 gene. During DNA repair, the enzyme hydrolyses oxidized purines and prevents their addition onto the DNA chain. As such it has important role in aging and cancer development.

Cat. No.	製品名	CAS No.	Purity
T2069	TH287	1609960-30-6	97.73%
TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
T2069L	TH287 hydrochloride	1638211-05-8	99.5%
TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeut...
T2037	TH588	1609960-31-7	99.57%
TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
T2S1635	3-Isomangostin	19275-46-8	99.76%
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has f...
T6357	(S)-crizotinib	1374356-45-2	99.89%
(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.
T12122	MTH1-IN-2	901044-91-5	98%
MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.

Cat. No.

製品名

CAS No.

Purity

Chemical Structure

T2069

TH287

1609960-30-6

97.73%

TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.

T2069L

TH287 hydrochloride

1638211-05-8

99.5%

TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeut...

T2037

TH588

1609960-31-7

99.57%

TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.

T2S1635

3-Isomangostin

19275-46-8

99.76%

3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has f...

T6357

(S)-crizotinib

1374356-45-2

99.89%

(S)-crizotinib (ent-crizotinib) （IC50 of 72 nM）, an effective MTH1 (NUDT1) inhibitor, is the (S)-enantiomer of crizotinib.

T12122

MTH1-IN-2

901044-91-5

98%

MTH1-IN-2 is an inhibitor of MutT homolog 1 (MTH1), with anti-tumor activity.