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MT Receptor

Melatonin receptors are G protein-coupled receptors (GPCR) which bind melatonin. Three types of melatonin receptors have been cloned. The MT1 (or Mel1A or MTNR1A) and MT2 (or Mel1B or MTNR1B) receptor subtypes are present in humans and other mammals, while an additional melatonin receptor subtype MT3 (or Mel1C or MTNR1C) has been identified in amphibia and birds. The receptors are crucial in the signal cascade of melatonin. In the field of chronobiology, melatonin has been found to be a key player in the synchrony of biological clocks. Melatonin secretion by the pineal gland has circadian rhythmicity regulated by the suprachiasmatic nucleus (SCN) found in the brain. The SCN functions as the timing regulator for melatonin; melatonin then follows a feedback loop to decrease SCN neuronal firing. The receptors MT1 and MT2 control this process. Melatonin receptors are found throughout the body in places such as the brain, the retina of the eye, the cardiovascular system, the liver and gallbladder, the colon, the skin, the kidneys, and many others.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T34081 Piromelatine 946846-83-9 98%
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
T10198 8-M-PDOT 134865-70-6 98%
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to s...
T60523 Agomelatine hydrochloride 1176316-99-6 100%
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for ...
T9193 ACH-000143 2225836-30-4 98.05%
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T3495 Tasimelteon 609799-22-6 98.64%
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T15795 Luzindole 117946-91-5 98.96%
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like acti...
T2O2728 Glycine 56-40-6 99.54%
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also ...
T14042 4-P-PDOT 134865-74-0 99.68%
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
T16834 S26131 296280-56-3 99.69%
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of ...
T1463 Ramelteon 196597-26-9 99.94%
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
Piromelatine
T34081
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibito...
8-M-PDOT
T10198
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to s...
Agomelatine hydrochloride
T60523
Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) is a specific MT1 and MT2 receptor agonist with Ki of 0.1 nM for CHO-hMT1, 0.06 nM for ...
ACH-000143
T9193
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
Tasimelteon
T3495
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
Luzindole
T15795
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like acti...
glycine
T2O2728
glycine (2-Aminoacetic acid) is a non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also ...
4-P-PDOT
T14042
4-P-PDOT (4-phenyl-2- propionamidotetralin) is a potent, selective and affinity Melatonin receptor (MT2) antagonist.
S26131
T16834
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of ...
Ramelteon
T1463
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.