| T9698 |
UC2288
|
1394011-91-6
|
98%
|
|
|
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein sta...
|
| T6965 |
RG7112
|
939981-39-2
|
|
|
|
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
|
| T12040 |
Milademetan
|
1398568-47-2
|
100%
|
|
|
Milademetan (DS-3032) is an orally active and potent MDM2 inhibitor with antitumor activity that induces G1 cell cycle arrest, senescence, and apoptosis.Milademe...
|
| T11980 |
MD-224
|
2136247-12-4
|
100%
|
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
|
| T21578 |
NSC 66811
|
6964-62-1
|
96.94%
|
|
|
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a...
|
| T2243 |
Serdemetan
|
881202-45-5
|
97.13%
|
|
|
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
|
| T3653 |
MX69
|
1005264-47-0
|
97.27%
|
|
|
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
|
| T1798 |
RITA
|
213261-59-7
|
97.76%
|
|
|
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt t...
|
| T28509 |
RDR03871
|
286008-51-3
|
97.78%
|
|
|
RDR03871 is an MDM2 inhibitor.
|
| T16771 |
RO-5963
|
1416663-77-8
|
98%
|
|
|
RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
|
| T6585 |
SAR405838
|
1303607-60-4
|
98.04%
|
|
|
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
|
| T16523L |
PhiKan 083
|
880813-36-5
|
98.2%
|
|
|
PhiKan 083 is a carbazole derivative
|
| T72026 |
P53-MDM2-IN-1
|
381717-91-5
|
98.3%
|
|
|
p53-MDM2-IN-1 (Example 30), an inhibitor targeting the p53-MDM2/X protein interaction, exhibits a K i value of 23.35 µM. This compound holds potential for applic...
|
| T2179 |
Triptolide
|
38748-32-2
|
98.52%
|
|
|
Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive,...
|
| T14303 |
Alrizomadlin
|
1818393-16-6
|
98.79%
|
|
|
Alrizomadlin (APG-115) is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and...
|
| T6614 |
Nutlin-3b
|
675576-97-3
|
98.83%
|
|
|
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-...
|
| TQ0127 |
Navtemadlin
|
1352066-68-2
|
98.86%
|
|
|
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
|
| T3517 |
RO8994
|
1309684-94-3
|
98.87%
|
|
|
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
|
| TQ0231 |
NVP-CGM097
|
1313363-54-0
|
98.92%
|
|
|
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
|
| T6610 |
XI-006
|
58131-57-0
|
99.12%
|
|
|
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
|
