T67698 |
WAY-300374
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WAY-300374 inhibits the p53-MDM2 protein-protein interaction.
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TN4107 |
Ganoderic acid X
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Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
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TQ0127 |
Navtemadlin
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AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
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T16771 |
RO-5963
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RO-5963 is a dual inhibitor of p53-MDM2 and p53-MDMX (IC50s: ~17 nM and ~24 nM, respectively).
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T6585 |
SAR405838
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MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
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T12031 |
MI-1061
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MI-1061 is a orally bioavailable inhibitor of MDM2 (MDM2-p53 interaction) (IC50=4.4 nM).
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TN4341 |
IVHD-valtrate
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VHD-valtrate has anticancer effects against human ovarian cancer cells in vitro and in vivo, it is a potential therapeutic agent for ovarian cancer, providing a ...
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TN1805 |
Isosilybin B
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Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it has anti-prostate cancer (PCA) activit...
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T12040 |
Milademetan
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Milademetan is a specific and oral inhibitor of MDM2.
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T11931 |
MA242
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MA242 is a nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy and dual inhibitor of murine double minute 2 (MDM2).
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T14203 |
AM-8735
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AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
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T12027 |
MG-277
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MG-277 is a molecular glue compound transformed from PROTAC degradation agent, MG-277 potently inhibits tumor cell growth in a p53-independent manner.
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T28509 |
RDR03871
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RDR03871 is an MDM2 inhibitor.
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T9698 |
UC2288
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UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein sta...
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T11980 |
MD-224
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MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
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T2243 |
Serdemetan
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Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
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T16523L |
PhiKan 083
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PhiKan 083 is a carbazole derivative
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T2179 |
Triptolide
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Triptolide is a diterpenes trioxide, immunosuppressive agent extracted from the Chinese herb Tripterygium wilfordii.
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T14303 |
Alrizomadlin
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Alrizomadlin is an orally active inhibitor of MDM2 with IC50 of 3.8 nM and Ki of 1 nM, respectively[1]. Alrizomadlin blocks the interaction of MDM2 and p53 and i...
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T6614 |
Nutlin-3b
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Nutlin-3b is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nu...
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T1798 |
RITA
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RITA(NSC 652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 i...
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T3517 |
RO8994
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RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding ...
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TQ0231 |
NVP-CGM097
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NVP-CGM097 is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
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T21773 |
SP-141
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SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
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T1919 |
Tenovin-1
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Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
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T6254 |
Idasanutlin
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Idasanutlin (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
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T3653 |
MX69
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MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
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T16888 |
SJ-172550
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SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
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T6965 |
RG7112
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RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
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T3184 |
Kevetrin hydrochloride
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Kevetrin hydrochloride is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
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T6610 |
NSC-207895
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NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
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T21578 |
NSC 66811
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NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a...
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