NOD-like Receptor (NLR)

The nucleotide-binding oligomerization domain-like receptors, or NOD-like receptors (NLRs) (also known as nucleotide-binding leucine-rich repeat receptors), are intracellular sensors of pathogen-associated molecular patterns (PAMPs) that enter the cell via phagocytosis or pores, and damage-associated molecular patterns (DAMPs) that are associated with cell stress. They are types of pattern recognition receptors (PRRs), and play key roles in the regulation of innate immune response. NLRs can cooperate with toll-like receptors (TLRs) and regulate inflammatory and apoptotic response. They are found in lymphocytes, macrophages, dendritic cells and also in non-immune cells, for example in epithelium. NLRs are highly conserved through evolution. Their homologs have been discovered in many different animal species (APAF1) and also in the plant kingdom (disease-resistance R protein).

Cat. No.	製品名	CAS No.	Purity
T41245	Trimethylamine N-oxide	1184-78-7	98%
T41245	Trimethylamine N-oxide (TMAO) is a colorless amine oxide produced from choline, betaine, and carnitine via intestinal microbial metabolism that accumulates in ti...
T4164	CY-09	1073612-91-5	98%
T4164	CY-09 is an NLRP3 inhibitor.
T6454	CORM-3	475473-26-8
T6454	CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.
T2893	Muscone	541-91-3
T2893	Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T13375	YQ128	2454246-18-3
T13375	YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
T15052	Dapansutrile	54863-37-5
T15052	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
T0772	Troxerutin	7085-55-4	95%
T0772	Troxerutin (Trihydroxyethylrutin), a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.
T6S1256	Ruscogenin	472-11-7	98.12%
T6S1256	1. Ruscogenin has anti-inflammatory activity, suppressed zymosan A-evoked peritoneal total leukocyte migration in mice in a dose-dependent manner, 2. Ruscogenin ...
T6887	MCC950 sodium	256373-96-3	98.16%
T6887	MCC950 sodium (CP-456773 sodium) is a potent and selective inhibitor of the inflammatory vesicle NLRP3 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs). MCC950 sodiu...
T3092	Nigericin sodium salt	28643-80-3	98.2%
T3092	Nigericin sodium salt is an antibiotic, an NLRP3 activator, and a cationic ion carrier. Nigericin sodium triggers the activation of the NALP3 inflammasome, which...
T77579	JC2-11	937820-89-8	98.6%
T77579	JC2-11 is an inhibitory compound for inflammation.JC2-11 inhibits the recruitment domain-containing proteins NLRC 4, atypical in melanoma 2 (AIM 2) and atypical ...
T1404	Stavudine	3056-17-5	98.91%
T1404	Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
T3230	NLRP3-IN-2	16673-34-0	98.98%
T3230	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation o...
T3587	NOD-IN-1	132819-92-2	99.43%
T3587	NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
TQ0165	Arglabin	84692-91-1	99.62%
TQ0165	Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.
T4217	INF39	866028-26-4	99.67%
T4217	INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.
T6591	Nodinitib-1	799264-47-4	99.98%
T6591	Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 μM.
T9222	Emlenoflast	1995067-59-8	98%
T9222	Emlenoflast (MCC7840) is a selective inhibitor of NLRP3 inflammasome.
T73015	NLRP3-IN-16	2906872-59-9	98%
T73015	NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in...
T82621	D359-0396	1031977-31-7	98%
T82621	D359-0396 is an orally active NLRP3 inflammasome inhibitor that mitigates pyroptosis and reduces IL-1β release in macrophages by inhibiting the oligomerization o...