| TP1973L |
OXA (17-33) acetate
|
|
98%
|
|
|
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).
|
| T3347 |
PF3274167
|
900510-03-4
|
|
|
|
PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.
|
| TP1045L |
Orexin B, rat, mouse Acetate
|
TP1045L
|
94.61%
|
|
|
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.
|
| T67782 |
Daridorexant hydrochloride
|
1792993-84-0
|
98%
|
|
|
Daridorexant hydrochloride (Nemorexant hydrochloride) is a New Dual Orexin Receptor Antagonist. Daridorexant hydrochloride can be used for Insomnia research.
|
| T2613 |
Almorexant
|
871224-64-5
|
98.02%
|
|
|
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and...
|
| T5503 |
IPSU
|
1373765-19-5
|
98.1%
|
|
|
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.
|
| T6658 |
SB-408124
|
288150-92-5
|
98.14%
|
|
|
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over...
|
| T1913 |
MK-3697
|
1224846-01-8
|
98.15%
|
|
|
MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).
|
| T39229 |
YNT-185
|
1804978-81-1
|
98.6%
|
|
|
YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R, respectivel...
|
| T4965 |
TCS-OX2-29
|
372523-75-6
|
99.08%
|
|
|
TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.
|
| T3177 |
Orexin 2 Receptor Agonist
|
1796565-52-0
|
99.14%
|
|
|
Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.
|
| T16096 |
Filorexant
|
1088991-73-4
|
99.33%
|
|
|
Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).
|
| T26559 |
ACT-462206
|
1361321-96-1
|
99.45%
|
|
|
ACT-462206 is an orally available Orexin 1/Orexin 2 receptor antagonist that crosses the blood-brain barrier.ACT-462206 is highly potent and can be used in studi...
|
| T5498 |
SB-649868
|
380899-24-1
|
99.58%
|
|
|
SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).
|
| T6140 |
SB-334867 free base
|
792173-99-0
|
99.69%
|
|
|
SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.
|
| T5500 |
DORA-22
|
1088991-95-0
|
99.73%
|
|
|
DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory
|
| T2710 |
TCS 1102
|
916141-36-1
|
99.76%
|
|
|
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).
|
| T12877L |
Seltorexant
|
1293281-49-8
|
99.83%
|
|
|
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective...
|
| T3722 |
MK-1064
|
1207253-08-4
|
99.88%
|
|
|
MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).
|
| T16854 |
SB-674042
|
483313-22-0
|
99.9%
|
|
|
SB-674042 is a potent and selective dual antagonist of the non-peptide orexigenic peptides OX1 and OX2 receptors, with IC50s of 3.76 nM and 531 nM, respectively....
|
