P2Y Receptor

P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate, and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14. P2Y receptors are present in almost all human tissues where they exert various biological functions based on their G-protein coupling. P2Y receptors mediate responses including vasodilation, blood clotting, and immune response. Due to their ubiquity and variety in function, they are a common biological target in pharmacological development.

Cat. No.	製品名	CAS No.	Purity
T4743	Uridine 5′-diphosphoglucose disodium salt	28053-08-9	98%
T4743	Uridine 5′-diphosphoglucose disodium salt (UDP-Glucose sodium salt) is an endogenous nucleotide sugar involved in glycosyltransferase reactions in Metabolism. It...
T6952	Prasugrel Hydrochloride	389574-19-0	98%
T6952	Prasugrel Hydrochloride (LY 640315 Hydrochloride) is a piperazine derivative and pletelet aggregation inhibitor that is used to prevent thrombosis in patients wi...
T4706	Uridine-5'-diphosphate disodium salt	27821-45-0	98%
T4706	Uridine-5'-diphosphate disodium salt (UDP disodium salt) is a specific agonist of the P2Y6 receptors (EC50 = 13 nM for human P2Y6), stimulating the production of...
T6172	MRS 2578	711019-86-2	98%
T6172	MRS2578, an effective P2Y6 receptor antagonist with IC50 of 37 nM, shows insignificant inhibition at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
T0179	Ticagrelor	274693-27-5	100%
T0179	Ticagrelor (AR-C 126532XX), produced by AstraZeneca, is an inhibitor of platelet aggregation. Unlike clopidogrel, ticagrelor is not a prodrug required metabolic ...
T12530	PPTN	1160271-30-6	100%
T12530	PPTN is a high-affinity, competitive and highly selective antagonist of P2Y14 receptor(KB value of 434 pM), with anti-inflammatory and immune activity.
T34280	Regrelor disodium	676251-22-2	100%
T34280	Regrelor disodium (INS 50589) is a p2y12 receptor antagonist that prevents thrombosis, effectively inhibits vascular smooth muscle cell contraction, inhibits cel...
T8582	1-[(5-methylisoxazol-3-yl)methyl]piperazine	173850-51-6	95%
T8582	1-[(5-methylisoxazol-3-yl)methyl]piperazine (Piperazine, 1-[(5-methyl-3-isoxazolyl)methyl]- (9CI)) is a P2Y12 inhibitor.
T83637	SYL-4	6222-65-7	95.76%
T83637	SYL-4 is a potential P2Y12 receptor antagonist with a Ki value of 7.35 ± 1.72 for use in synthetic dyes.
T11177	Elinogrel	936500-94-6	97.09%
T11177	Elinogrel (PRT060128) is a competitive and reversible antagonist of platelet P2Y12 with IC50 of 20 nM and exhibits potent antiplatelet effects.
T3536	AZD1283	919351-41-0	98.37%
T3536	AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibi...
T0182	Clopidogrel	113665-84-2	98.47%
T0182	Clopidogrel (SR-25990C), a P2Y12 receptor antagonist, decreases platelet aggregation.
T0230	Prasugrel	150322-43-3	98.62%
T0230	Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNS...
T23164	PIT	56583-49-4	99.01%
T23164	PIT (2,2'-Pyridylisatogen tosylate) is a specific and non-competitive antagonist of the Purinergic receptor P2Y1 with an IC50 of 0.14 μM for human P2Y1. PIT does...
T21059	Ticagrelor metabolite M5	1251765-07-7	99.09%
T21059	Ticagrelor metabolite M5 (T437700) is a metabolite of Ticagrelor, the first reversible oral antagonist of P2Y12 receptor. Compared to Clopidogrel, Ticagrelor has...
T5036	Cangrelor tetrasodium	163706-36-3	99.15%
T5036	Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects.
T12164	N6-(4-Hydroxybenzyl)adenosine	110505-75-4	99.18%
T12164	N6-(4-Hydroxybenzyl)adenosine (Para-topolin riboside) is a platelet aggregation inhibitor.
T0182L	Clopidogrel hydrogen sulfate	120202-66-6	99.51%
T0182L	Clopidogrel hydrogen sulfate ((S)-(+)-Clopidogrel bisulfate) , a selective, high-affinity P2Y12 receptor antagonist, suppressess fibrinogen binding to platelets ...
T0182L2	(±) Clopidogrel hydrogen sulfate	135046-48-9	99.62%
T0182L2	(±) Clopidogrel hydrogen sulfate (Iscover) , an antiplatelet agent pharmacologically and structurally analogous to ticlopidine, is used to inhibit blood clots in...
T7423	Diquafosol tetrasodium	211427-08-6	99.68%
T7423	Diquafosol Tetrasodium is a P2Y2 receptor agonist that stimulates the secretion of mucins from ocular tissues Diquafosol tetrasodium (INS365) improves tear film ...