T0293 |
Metyrapone
|
54-36-4
|
98%
|
|
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the ...
|
T9704 |
1-Ethynylpyrene
|
34993-56-1
|
98%
|
|
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).
|
T117521 |
7-BFC
|
220001-53-6
|
98%
|
|
7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study...
|
TN1482 |
Chamaechromone
|
93413-00-4
|
98%
|
|
Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
|
TN1078 |
Seneciphylline
|
480-81-9
|
98%
|
|
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significa...
|
T67926 |
(S)-(+)-N-3-Benzylnirvanol
|
790676-40-3
|
98%
|
|
(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection.
|
T3668 |
Galangin
|
548-83-4
|
98%
|
|
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
|
T3941 |
Choline Fenofibrate
|
856676-23-8
|
98%
|
|
Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity...
|
T7056 |
Dronedarone
|
141626-36-0
|
98%
|
|
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
|
T21425 |
Mephenytoin
|
50-12-4
|
98%
|
|
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
|
TN1011 |
Rhodionin
|
85571-15-9
|
98%
|
|
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
|
T19526 |
Pradefovir mesylate
|
625095-61-6
|
98%
|
|
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
|
T36125 |
Tienilic Acid
|
40180-04-9
|
98%
|
|
Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity
|
T1443 |
Memantine hydrochloride
|
41100-52-1
|
98%
|
|
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
|
T0660 |
Beta-Tetralone
|
530-93-8
|
98%
|
|
Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
|
T67916 |
CYP4A11/CYP4F2-IN-2
|
2126874-77-7
|
98%
|
|
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CY...
|
T73042 |
CYP1B1-IN-5
|
176442-56-1
|
98%
|
|
CYP1B1-IN-5 is a selective and potent cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.CYP1B1-IN-5 can be used for the study of metabolism-related d...
|
T72501 |
CYP4A11/CYP4F2-IN-1
|
502654-40-2
|
98%
|
|
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebro...
|
T2878 |
Ginsenoside Rd
|
52705-93-8
|
98%
|
|
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
|
TQ0217 |
Gomisin G
|
62956-48-3
|
98%
|
|
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
|