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P450

Cytochromes P450 (CYPs) are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds, as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. The term "P450" is derived from the spectrophotometric peak at the wavelength of the absorption maximum of the enzyme (450 nm) when it is in the reduced state and complexed with carbon monoxide. Most CYPs require a protein partner to deliver one or more electrons to reduce the iron (and eventually molecular oxygen).
Cat. No. 製品名 CAS No. Purity Chemical Structure
T0293 Metyrapone 54-36-4 98%
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the ...
T9704 1-Ethynylpyrene 34993-56-1 98%
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).
T117521 7-BFC 220001-53-6 98%
7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study...
TN1482 Chamaechromone 93413-00-4 98%
Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
TN1078 Seneciphylline 480-81-9 98%
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significa...
T67926 (S)-(+)-N-3-Benzylnirvanol 790676-40-3 98%
(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection.
T3668 Galangin 548-83-4 98%
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
T3941 Choline Fenofibrate 856676-23-8 98%
Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity...
T7056 Dronedarone 141626-36-0 98%
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T21425 Mephenytoin 50-12-4 98%
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
TN1011 Rhodionin 85571-15-9 98%
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
T19526 Pradefovir mesylate 625095-61-6 98%
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
T36125 Tienilic Acid 40180-04-9 98%
Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity
T1443 Memantine hydrochloride 41100-52-1 98%
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
T0660 Beta-Tetralone 530-93-8 98%
Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
T67916 CYP4A11/CYP4F2-IN-2 2126874-77-7 98%
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CY...
T73042 CYP1B1-IN-5 176442-56-1 98%
CYP1B1-IN-5 is a selective and potent cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.CYP1B1-IN-5 can be used for the study of metabolism-related d...
T72501 CYP4A11/CYP4F2-IN-1 502654-40-2 98%
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebro...
T2878 Ginsenoside Rd 52705-93-8 98%
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
TQ0217 Gomisin G 62956-48-3 98%
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
Metyrapone
T0293
Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the ...
1-Ethynylpyrene
T9704
1-Ethynylpyrene is an aryl acetylenic inhibitor of CYTP450 1A1(IC50=0.18 μM), 1A2(IC50 = 0.32 μM), and 2B1(IC50 = 0.04 μM).
7-BFC
T117521
7-BFC (7-Benzyloxy-4-(trifluoromethyl)coumarin) is a coumarin-like fluorescent substrate that serves as a biomarker for cytochrome P 450 and can be used to study...
Chamaechromone
TN1482
Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.
Seneciphylline
TN1078
Seneciphylline, one of the hepatotoxic pyrolizidine alkaloids, has mutagenic activity in Drosophila and their transfer into rat milk.Seneciphylline can significa...
(S)-(+)-N-3-Benzylnirvanol
T67926
(S)-(+)-N-3-Benzylnirvanol (ZSN-76403) is a cytochrome P450 CYP2C19 inhibitor with an IC50 value of 0.179 µM that can be used to study HIV infection.
Galangin
T3668
Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor, and also shows inhibition of CYP1A1 activity.
Choline Fenofibrate
T3941
Choline Fenofibrate (Trilipix) is a choline formulation of fenofibrate, a synthetic phenoxy-isobutyric acid derivate and prodrug with antihyperlipidemic activity...
Dronedarone
T7056
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
Mephenytoin
T21425
Mephenytoin (Phenantoin) is an anticonvulsant and a substrate of CYP2C19 and CYP2B6.
Rhodionin
TN1011
Rhodionin and rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administer...
Pradefovir mesylate
T19526
Pradefovir mesylate (Hepavir B) is converted to 9-(2-phosphonylmethoxyethyl)adenine (PMEA) in human liver microsomes with Km of 60 μM.
Tienilic Acid
T36125
Tienilic Acid is a uricosuric diuretic with certain hepatotoxicity
Memantine hydrochloride
T1443
Memantine hydrochloride (Memantine HCl) is an AMANTADINE derivative that has some dopaminergic effects. Memantine hydrochloride has been proposed as an antiparki...
Beta-Tetralone
T0660
Beta-Tetralone (2-Tetralone) is a ketone derivative of tetralin.
CYP4A11/CYP4F2-IN-2
T67916
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CY...
CYP1B1-IN-5
T73042
CYP1B1-IN-5 is a selective and potent cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 4.7 nM.CYP1B1-IN-5 can be used for the study of metabolism-related d...
CYP4A11/CYP4F2-IN-1
T72501
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebro...
Ginsenoside Rd
T2878
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
Gomisin G
TQ0217
Gomisin G is a natural compound and exhibits potent anti-HIV activity (EC50: 0.006 μg/mL; therapeutic index: 300). It is a good substrate of CYP2C9.
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