PAI-1

Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis,PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1).The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease nexin acts as an inhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of the plasminogen activators.

Cat. No.	製品名	CAS No.	Purity
T2030	Tiplaxtinin	393105-53-8
T2030	Tiplaxtinin (Tiplasinin)(PAI-039) is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 2.7 uM.
T3442	UK-371804	256477-09-5	95.81%
T3442	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulc...
T8962	TM5007	342595-05-5	96.91%
T8962	TM5007 is a poent inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 of 29 uM).
T29856	Aleplasinin	481629-87-2	97.51%
T29856	Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic sys...
T23764	AZ3976	1418747-15-5	98.01%
T23764	AZ3976 is an inhibitor of PAI-1 with an IC50 of 16 μM in a plasma clot lysis assay. AZ3976 displays profibrinolytic activities.
T13257	Upamostat	590368-25-5	98.80%
T13257	Upamostat is an inhibitor of a serine protease and is a urokinase plasminogen activator (uPA) inhibitor.
T4254	TM5441	1190221-43-2	98.87%
T4254	TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T9947	GW-6604	452342-37-9	99.26%
T9947	GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.
T26629	Angstrom6	220334-14-5	99.36%
T26629	Angstrom6 (A-6 peptide) is an 8 amino acid peptide derived from single chain urokinase fibrinogen activator (scuPA) that interferes with the uPA/uPAR cascade and...
T4255	TM5275 sodium	1103926-82-4	99.55%
T4255	TM5275 sodium (TM5275 sodium salt) is an inhibitor of plasminogen activator inhibitor 1 (PAI-1).
T4S0592	Toddalolactone	483-90-9	99.85%
T4S0592	Toddalolactone ((+)-Toddalolactone) is an anti-inflammatory and analgesic.
T3876	Loureirin B	119425-90-0	99.91%
T3876	Loureirin B can downregulate the expression of fibrosis-related molecules by regulating MMPs and TIMPs levels, inhibit scar fibroblast proliferation and suppress...