| T4230 |
PF-3758309 hydrochloride
|
1279034-84-2
|
98%
|
|
|
PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (P...
|
| T6546 |
IPA-3
|
42521-82-4
|
98%
|
|
|
IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
|
| T6839 |
FRAX1036
|
1432908-05-8
|
98%
|
|
|
FRAX-1036 is a effective and selective PAK1 inhibitor.
|
| T23160 |
PIR 3.5
|
6088-51-3
|
97.02%
|
|
|
PIR 3.5 (6,6′-Dithiodi(2-naphthol)) is a negative control of IPA 3 which is a Pak1 inhibitor.
|
| T0646 |
5-Aminosalicylic Acid
|
89-57-6
|
97.88%
|
|
|
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is consid...
|
| T60269 |
ZINC194100678
|
1995025-05-2
|
98.3%
|
|
|
ZINC194100678 is an effective PAK1 inhibitor with IC50 of 8.37μM. ZINC194100678 showed strong anti-proliferation activity, with IC50 value of 40.16μM against MDA...
|
| T26704 |
AZ13705339
|
2016806-57-6
|
98.57%
|
|
|
AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in s...
|
| T6840 |
FRAX486
|
1232030-35-1
|
98.81%
|
|
|
FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
|
| T16429 |
GNE 2861
|
1394121-05-1
|
99.07%
|
|
|
GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.
|
| T6840L |
FRAX486 HCL(1232030-35-1 free base)
|
T6840L
|
99.17%
|
|
|
FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
|
| T11826 |
LCH-7749944
|
796888-12-5
|
99.28%
|
|
|
LCH-7749944 (GNF-PF-2356) effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and ...
|
| T2539 |
Fingolimod hydrochloride
|
162359-56-0
|
99.29%
|
|
|
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
|
| T6626 |
PF-3758309
|
898044-15-0
|
99.37%
|
|
|
PF-3758309 (PF-03758309) (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.
|
| T11342L |
G-5555
|
1648863-90-4
|
99.70%
|
|
|
G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
|
| T4354 |
KPT9274
|
1643913-93-2
|
99.73%
|
|
|
KPT9274 (PAK4-IN-1) is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.
|
| T16367 |
NVS-PAK1-1
|
1783816-74-9
|
99.74%
|
|
|
NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).
|
| T6014 |
FRAX597
|
1286739-19-2
|
99.75%
|
|
|
FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
|
| T7939 |
Fingolimod
|
162359-55-9
|
99.76%
|
|
|
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
|
| T11342 |
G-5555 hydrochloride (1648863-90-4 free base)
|
T11342
|
98%
|
|
|
G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
|
| T81569 |
PAK4-IN-3
|
|
98%
|
|
|
PAK4-IN-3 (compound 27e) is a PAK4 inhibitor exhibiting an IC50 of 10 nM and demonstrates antiproliferative effects on A549 cells with an IC50 of 0.61μM. It also...
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