| T1895 |
SKLB 610
|
1125780-41-7
|
98%
|
|
|
SKLB610, a novel multi-targeted inhibitor, inhibits angiogenesis-related tyrosine kinase VEGFR2, FGFR2, and PDGFR at a rate of 97%, 65%, and 55%, respectively, a...
|
| T16947 |
SU16f
|
251356-45-3
|
98%
|
|
|
SU16f (3-substituted indolin-2-one 16f) is a potent and selective PDGFRβ inhibitor (IC50s: 10 nM, 140 nM, 2.29 μM for PDGFRβ, PDGFR1, PDGFR2, respectively). Neut...
|
| T8900 |
Seralutinib
|
1619931-27-9
|
98%
|
|
|
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension.
|
| T76761 |
Olaratumab
|
1024603-93-7
|
98%
|
Olaratumab
|
|
Olaratumab(IMC-3G3) is a human monoclonal IgG1 antibody against platelet-derived growth factor receptor alpha (PDGFRα), which has antitumor effects and can be us...
|
| T4320 |
Flumatinib
|
895519-90-1
|
98%
|
|
|
Flumatinib (HHGV678) is an orally bioavailable tyrosine kinase inhibitor flumatinib, with potential antineoplastic activity.
|
| T8544 |
Masitinib mesylate
|
1048007-93-7
|
98%
|
|
|
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα...
|
| T13156L |
TG 100572 Hydrochloride
|
867331-64-4
|
98%
|
|
|
TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1...
|
| T4315 |
Ki20227
|
623142-96-1
|
|
|
|
Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
|
| TQ0235 |
AC710
|
1351522-04-7
|
|
|
|
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
|
| TQ0317 |
R1530
|
882531-87-5
|
|
|
|
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
|
| T9030 |
SU4984
|
186610-89-9
|
100%
|
|
|
SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
|
| T7104 |
Dovitinib lactate
|
692737-80-7
|
100%
|
|
|
Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).
|
| T2372L |
Ponatinib Hydrochloride
|
1114544-31-8
|
100%
|
|
|
Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.3...
|
| T6720 |
Vatalanib dihydrochloride
|
212141-51-0
|
100%
|
|
|
Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR. It exhibits less effective against VEGFR1/Flt-1 and 18-fold against...
|
| T8402 |
Regorafenib Hydrochloride
|
835621-07-3
|
100%
|
|
|
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with pote...
|
| T6184 |
Orantinib
|
252916-29-3
|
100%
|
|
|
Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It ...
|
| T35570 |
Chiauranib
|
1256349-48-0
|
96.25%
|
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
|
| T8976 |
PD-089828
|
179343-17-0
|
96.78%
|
|
|
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitiv...
|
| T67847 |
Imatinib impurities3
|
404844-11-7
|
97.05%
|
|
|
Imatinib impurities3 is a protein kinases inhibitor with IC50 values of 6.95uM, 0.245uM, 0.139uM for ABL1 wt, KIT wt, PDGFRR wt, respectively.
|
| T13178 |
Toceranib
|
356068-94-5
|
97.14%
|
|
|
Toceranib (PHA 291639E) phosphate is an orally active inhibitor of tyrosine kinase (RTK) receptor, and it potently inhibits PDGFR, VEGFR, and Kit(with Kis of 5 a...
|
