| T0809 |
Dicoumarol
|
66-76-2
|
98%
|
|
|
Dicoumarol (Dicumarol) is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicoumarol ...
|
| T4046 |
BX517
|
850717-64-5
|
98%
|
|
|
BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1.
|
| T19783 |
Dehydroabiethylamine
|
1446-61-3
|
98%
|
|
|
Dehydroabiethylamine (NSC-2955) is an inducer of hepatic CYP2B activity. Dehydroabiethylamine inhibits pyruvate dehydrogenase kinases (PDKs) and intracellular ch...
|
| T12412L |
PDK4-IN-1 hydrochloride
|
2310262-11-2
|
98%
|
|
|
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)
|
| TMA2474 |
δ-Tocotrienol
|
25612-59-3
|
97.38%
|
|
|
δ-Tocotrienol (Delta-Tocotrienol) is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung...
|
| T3163 |
PS 48
|
1180676-32-7
|
98%
|
|
|
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
|
| T2420 |
PHT-427
|
1191951-57-1
|
98%
|
|
|
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
|
| T24741 |
RS1-PDK1 inhibitor
|
1643958-85-3
|
98.25%
|
|
|
RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.
|
| T1830 |
BX795
|
702675-74-9
|
98.32%
|
|
|
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
|
| T11765 |
KPLH1130
|
906669-07-6
|
98.43%
|
|
|
KPLH1130, a specific pyruvate dehydrogenase kinase (PDK) inhibitor, enhances glucose tolerance in mice fed a high-fat diet (HFD). It effectively hinders macropha...
|
| T24677 |
PS47
|
1180676-33-8
|
98.61%
|
|
|
PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
|
| T2348 |
GSK2334470
|
1227911-45-6
|
98.65%
|
|
|
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
|
| T77685 |
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
|
1207836-10-9
|
98.81%
|
|
|
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study angiosarcoma...
|
| T17224 |
VER-246608
|
1684386-71-7
|
98.88%
|
|
|
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK...
|
| T2466 |
Osu03012
|
742112-33-0
|
99.22%
|
|
|
Osu03012 (AR-12) is an orally bioavailable, small-molecule, celecoxib-derived inhibitor of phosphoinositide-dependent kinase-1 (PDK1) with potential antineoplast...
|
| T1837 |
BX-912
|
702674-56-4
|
99.34%
|
|
|
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
|
| T3895 |
Polyphyllin I
|
50773-41-6
|
99.36%
|
|
|
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, c...
|
| T6084 |
Rabusertib
|
911222-45-2
|
99.40%
|
|
|
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials stu...
|
| T12398 |
MP7
|
1001409-50-2
|
99.45%
|
|
|
MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
|
| T16670 |
PS210
|
1221962-86-2
|
99.65%
|
|
|
PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1, without acting against other protein kinases...
|
