| TN2019 |
Orobol
|
480-23-9
|
98%
|
|
|
Orobol (3’,4’,5,7-tetrahydroxy-isoflavon) is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover. Orobol inhibits PI3K isoforms wi...
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| T39573 |
GSK251
|
2125968-05-8
|
98%
|
|
|
GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.
|
| T11129 |
Duvelisib (R enantiomer)
|
1261590-48-0
|
98%
|
|
|
Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.
|
| T9788 |
SN32976
|
1246202-11-8
|
98%
|
|
|
SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.
|
| T13386 |
Zandelisib
|
1401436-95-0
|
98%
|
|
|
Zandelisib is an inhibitor of phosphatidylinositol 3-kinase (PI3K)(p110δ, IC50 of 3.5 nM), and with antineoplastic activity.
|
| TQ0003L1 |
740 Y-P acetate
|
TQ0003L1
|
98%
|
|
|
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-te...
|
| T22339 |
GNE-490
|
1033739-92-2
|
98%
|
|
|
GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold ...
|
| T12459 |
PI3K/mTOR Inhibitor-2
|
1848242-58-9
|
98%
|
|
|
PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibi...
|
| T2061 |
APY0201
|
1232221-74-7
|
98%
|
|
|
APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (P...
|
| T21344 |
1-Deoxynojirimycin hydrochloride
|
73285-50-4
|
|
|
|
1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves. Duvoglustat is us...
|
| T36083 |
DS-7423
|
1222104-37-1
|
|
|
|
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].
DS...
|
| T14214 |
AMG 511
|
1253573-53-3
|
|
|
|
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-t...
|
| T1894 |
Idelalisib
|
870281-82-6
|
|
|
|
Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/...
|
| T7343 |
PF-04979064
|
1220699-06-8
|
|
|
|
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
|
| T1970 |
Gedatolisib
|
1197160-78-3
|
|
|
|
Gedatolisib (PF-05212384) is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway...
|
| T6110 |
YM-201636
|
371942-69-7
|
|
|
|
YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.
|
| T4296 |
MTX-211
|
1952236-05-3
|
100%
|
|
|
MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.
|
| T12115 |
MSC2360844
|
1305267-37-1
|
100%
|
|
|
MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
|
| T4220 |
BQR-695
|
1513879-21-4
|
100%
|
|
|
BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respe...
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