| T13605 |
Cercosporin
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Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes. Cercosporin is a potent photosensitizer with a short activation wavelengt...
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| T15638 |
K-252c
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K-252c is a staurosporine analog isolated from Nocardiopsis sp. and is a cell-permeable PKC inhibitor (IC50: 2.45 µM). K-252c also inhibits β-lactamase, chymotry...
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| T17299 |
(-)-Indolactam V
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(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2 , γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-...
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| TN2844 |
(2R,3S)-Dihydrodehydroconiferyl alcohol
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(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
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| TN4300 |
Isojacareubin
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Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
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| T5423 |
PKC-theta inhibitor
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PKC-theta inhibitor is PKC-θinhibitor, with an IC50 of 12 nM.
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| T15637 |
K-252b
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K-252b is an indolocarbazole isolated from the actinomycete Nocardiopsis and is a PKC inhibitor. K-252b can be used to inhibit extracellular kinases of cells in ...
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| TN2799 |
20-Deoxyingenol 3-angelate
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20-Deoxyingenol 3-angelate and ingenol 20-acetate 3-angelate are known as promoters of tumors of mouse skin. 20-Deoxyingenol 3-angelate can induce significant pl...
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| TN3655 |
Cimiside E
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Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/2,...
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| T4001 |
Euxanthone
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Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasod...
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| T13384 |
Y-33075
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Y-33075 is a selective inhibitor of ROCK derived from Y-27632, and is more potent than Y-27632, with an IC50 of 3.6 nM.
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| T10555 |
BJE6-106
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BJE6-106 (B106) is a potent, selective PKCδ inhibitor (IC50: 0.05 μM) and targets selectivity over classical PKCα (IC50: 50 μM). BJE6-106 induces caspase-depende...
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| T1606 |
Fasudil
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Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
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| TN2326 |
(Z)-Butylidenephthalide
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(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
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| T14831 |
Bryostatin 1
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Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain...
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| TN3517 |
Bisacurone
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Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
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| T3689 |
Ruboxistaurin hydrochloride
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Isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Sele...
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| T16848 |
SB-218078
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SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
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| T12496 |
PKC-theta inhibitor 1
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PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)
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| T10888 |
CRT0066854 hydrochloride
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CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
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| TN4431 |
Leucosceptoside A
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Leucosceptoside A shows inhibitory activity against PKCalpha with the IC50 value of 19.0 microM; it also exhibits strong inhibitory capacity against α-glucosidas...
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| T13637 |
DCP-LA
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DCP-LA (FR236924), linoleic acid derivatives, selective and direct activation of PKCε.
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| T16526 |
Phorbol 12,13-dibutyrate
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Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
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| TN1542 |
Cycloheterophyllin
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Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be u...
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| T16671 |
PS315
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PS315 inhibits the full-length and catalytic domain constructs of PKCζ (IC50=10 μM) and PKCη (IC50=30 μM). PS315 has anti-cancer activity. PS315 is a derivative ...
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| T14328 |
AS2521780
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AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
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| T6515 |
Go6976
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Go6976 is a small molecule inhibitor of protein kinase C (PKC). Go6976 has been widely used in biomedical research as a tool to study the role of PKC in various ...
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| TN3160 |
6-Deoxyisojacareubin
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6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibiti...
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| T35407 |
Ζ-Stat
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ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and...
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| T22464 |
1,2-Dimyristoyl-sn-glycerol
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1,2-dimyristoyl-sn-glycerol is able to increase AChE activity by 35-40% at concentrations of 25 micrograms/ml in the parasite S. mansoni..
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| T14943 |
CGP60474
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CGP60474 is an inhibitor of VEGFR-2 (IC50: 84 nM) and an ATP-competitive inhibitor of PKC.
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| TN4114 |
Gardenin A
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Gardenin A shows neurotrophic effects via activating MAPK/ERK, PKC, and PKA. Gardenin A exhibits antidepressant, anticonvulsant and anxiolytic effects.
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| T4444 |
A-674563 HCl (552325-73-2(free base))
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A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
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| T13363 |
Y06137
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Y06137 is an effective and selective BET inhibitor with a Kd of 81 nM for BRD4(1) bromodomain. Y06137 can be used for research on the treatment of castration-res...
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| T60109 |
Protein kinase inhibitor H-7
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Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) with a Ki of 6 μM. Protein kinase inhibitor H-7 is also a cyclic nucleotide dependen...
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| T7790 |
Bisindolylmaleimide V
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Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
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| TP1888L1 |
[Ala113]-MBP (104-118) acetate
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[Ala113]MBP(104-118) acetate is an noncompetitive peptide inhibitors of protein kinase C (PKC), with IC50s ranging from 28-62 μM.
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| T14072 |
A-443654
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A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
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| T17148 |
TPPB
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TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
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| TN1513 |
Clitorin
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Clitorin has free radical scavenging property. It shows significant interactions with CD38, it may have anti-hyperglycemic potential.
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| T20168 |
Aurothiomalate sodium
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Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor...
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| T8681 |
HA-1004 dihydrochloride
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HA-1004 dihydrochloride is an inhibitor of PKA, PKC, cGKI, MYLK, and calcium channel protein
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| T17019 |
TCS 21311
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TCS 21311 is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM). TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively)....
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| T11665 |
Ionomycin calcium
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lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase ...
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| TP1789L |
Malantide acetate(86555-35-3 free base)
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Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide tha...
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| TP1053L |
Protein Kinase C 19-31 acetate
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Protein Kinase C 19-31 acetate, a peptide inhibitor of protein kinase C (PKC), derived from the pseudo-substrate regulatory domain of PKCa (residues 19-31) with ...
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| T7885 |
Afuresertib hydrochloride
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Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
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| T8376 |
PKCβ inhibitor 1
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PKCβ inhibitor 1(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively).
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| TP1924L1 |
ZIP acetate(863987-12-6 free base)
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ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectiv...
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| TP1955L |
PKC β pseudosubstrate acetate
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PKC β pseudosubstrate acetate is a selective cell-permeable inhibitor of PKC.
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