PKM

Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic thyroid hormone-binding protein (CTHBP), thyroid hormone-binding protein 1 (THBP1), or opa-interacting protein 3 (OIP3), is an enzyme that in humans is encoded by the PKM2 gene.PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. Depending upon the different metabolic functions of the tissues, different isoenzymes of pyruvate kinase are expressed. PKM2 is expressed in some differentiated tissues, such as lung, fat tissue, retina, and pancreatic islets, as well as in all cells with a high rate of nucleic acid synthesis, such as normal proliferating cells, embryonic cells, and especially tumor cells.

Cat. No.	製品名	CAS No.	Purity
T0745	Disodium monofluorophosphate	10163-15-2
T0745	Disodium monofluorophosphate (NSC248) is a competitive inhibitor of pyruvate kinase and alkaline phosphatase, which also irreversibly inhibits phosphorylase phos...
T62758	PKM2 activator 2	1186660-06-9	100%
T62758	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates th...
T8363	DL-Serine	302-84-1	98%
T8363	DL-Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.
T7214	TEPP-46	1221186-53-3	98.47%
T7214	TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation an...
T1125	Shikonin	517-89-5	98.54%
T1125	Shikonin (Anchusa acid) is a natural product, a TMEM16A chloride channel inhibitor (IC50=6.5 μM) and selective PKM2 inhibitor. Shikonin exhibits antitumor, anti-...
T6816	DASA-58	1203494-49-8	98.99%
T6816	DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.
T12499	PKR-IN-2	1628428-01-2	99.17%
T12499	PKR-IN-2 is a activator of pyruvate kinase (PKR).
T67900	PKM2 inhibitor G	904457-46-1	99.54%
T67900	PKM2 inhibitor G is a inhibitor of pyruvate kinase.
T60102L	Dimethylaminomicheliolide HCl	1403357-80-1	99.55%
T60102L	Dimethylaminomicheliolide HCl has potential anti-inflammatory and anti-tumor activity and inhibits the proliferation of glioblastoma cells by targeting pyruvate ...
T4223	Mitapivat	1260075-17-9	99.83%
T4223	Mitapivat (PKR-IN-1), also known as PKM2 activator 1020 is a PKM2 activator (pyruvate kinase activator) for the treatment of pyruvate kinase deficiency.
T4170	PKM2-IN-1	94164-88-2	99.9%
T4170	PKM2-IN-1 (compound 3k) displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
T72693	PKM2 activator 5	796092-26-7	98%
T72693	PKM2 activator 5 is a novel and potent PKM2 activator (AC50: 0.316 µM) with potential anticancer activity for the study of cancer metabolism-related diseases.