T7359 |
CAY10471 Racemate
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CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and...
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TN4463 |
Lupeolic acid
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Lupeolic acid has anti-inflammatory activity.
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TN1257 |
3-O-Acetyl-α-boswellic acid
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3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
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T63349 |
Treprostinil diethanolamine
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Treprostinil diethanolamine is a potent agonist of EP2, DP1 and IP. Treprostinil exhibits Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, I...
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TN1378 |
Alpha-Viniferin
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Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
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T16388 |
Omidenepag isopropyl
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Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
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TN5019 |
Siegeskaurolic acid
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Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
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T16988 |
Taprenepag isopropyl
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Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
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T14146 |
AGN 210676
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AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
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T2573 |
Misoprostol
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TN4748 |
Penduletin
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Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendule...
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T3P2855 |
Chamigrenal
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β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
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TN4194 |
Heliangin
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Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells...
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TMA0291 |
Dehydroglyasperin D
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Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
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TN4959 |
Schizandriside
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Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysacc...
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T17092 |
Tiaprost
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Tiaprost is a analog of prostaglandin F2α .
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T4484 |
1,7-Dihydroxy-2,3-methylenedioxyxanthone
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1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
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TN4303 |
Isokaempferide
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Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
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T16504 |
PF-4693627
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PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by oste...
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TN4635 |
Neoechinulin A
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Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
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TN4465 |
Luvangetin
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Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
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TN4162 |
Goshonoside F5
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Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
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TN4489 |
Manassantin A
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Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
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TN1622 |
Ermanin
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Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
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TN1009 |
Epimagnolin B
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Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
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TMA1570 |
Sappanone A
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Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
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TN4675 |
Nortrachelogenin
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Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
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TN1485 |
Chicanine
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Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
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T14500 |
BAY-1316957
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BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
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TN3582 |
Canniprene
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Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and als...
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T4624 |
PGD2-IN-1
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PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d)
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TN4592 |
Murrangatin
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Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
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TN4420 |
Latifolin
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Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
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TN1171 |
6-Dehydrogingerdione
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1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
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T16011 |
Manumycin A
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Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inh...
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T16389 |
Omidenepag
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Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays...
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TN5017 |
Sideritoflavone
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Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
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T2S0765 |
Epibetulinic acid
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Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
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TN5248 |
Voleneol
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1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
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T13466 |
(+)-Talarozole
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(+)-Talarozole is a potent retinoic acid metabolism inhibitor .
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T15642 |
KAG-308
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KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP...
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T13488 |
2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide
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2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pros...
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T12100 |
MPGES1-IN-3
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mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
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T14139 |
Aganepag
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Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of woun...
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T10046 |
16,16-Dimethyl prostaglandin E2
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16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an int...
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TN3366 |
Ailanthoidol
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Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
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T11340 |
Furprofen
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Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti-in...
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TN3839 |
Desoxo-narchinol A
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Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
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TN2115 |
Pseudohypericin
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Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
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T15690 |
L-902688
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L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid recep...
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