Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.

カタログ番号	製品名
T7359	CAY10471 Racemate	CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and...
TN4463	Lupeolic acid	Lupeolic acid has anti-inflammatory activity.
TN1257	3-O-Acetyl-α-boswellic acid	3-O-Acetyl-alpha-boswellic acid has strong anti-inflammatory activity.
T63349	Treprostinil diethanolamine	Treprostinil diethanolamine is a potent agonist of EP2, DP1 and IP. Treprostinil exhibits Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, I...
TN1378	Alpha-Viniferin	Alpha-viniferin is a prostaglandin H2 synthase inhibitor, which has anti-inflammatory, anti-oxidant, anti-arthritis, and anti-tumor activities.
T16388	Omidenepag isopropyl	Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenep...
TN5019	Siegeskaurolic acid	Siegeskaurolic acid exhibits anti-inflammatory and antinociceptive effects, which due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via...
T16988	Taprenepag isopropyl	Taprenepag isopropyl is a highly selective agonist of the EP2 receptor.
T14146	AGN 210676	AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).
T2573	Misoprostol
TN4748	Penduletin	Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Pendule...
T3P2855	Chamigrenal	β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 m...
TN4194	Heliangin	Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-ÎºB pathway on LPS-induced RAW 264.7 cells...
TMA0291	Dehydroglyasperin D	Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN4959	Schizandriside	Schizandriside may have anti-inflammatory effects, it has inhibitory activities against nitric oxide and prostaglandin E(2) production in IFN-γ- and lipopolysacc...
T17092	Tiaprost	Tiaprost is a analog of prostaglandin F2α .
T4484	1,7-Dihydroxy-2,3-methylenedioxyxanthone	1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesi...
TN4303	Isokaempferide	Isokaempferide shows hepatoprotective, antiproliferative, and anti-inflammatory effects, the anti-inflammatory effects can be explained, at least in part, by red...
T16504	PF-4693627	PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by oste...
TN4635	Neoechinulin A	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
TN4465	Luvangetin	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection agains...
TN4162	Goshonoside F5	Goshonoside F5 has anti-inflammatory activity, it significantly inhibits the pro-inflammatory response induced by LPS, both in vitro and in vivo.
TN4489	Manassantin A	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN1622	Ermanin	Ermanin shows anti-inflammatory activity by suppressing the iNOS and COX-2 expression. Ermanin may have anti-HIV-1activity. Ermanin also has a high deterrent act...
TN1009	Epimagnolin B	Epimagnolin B has anti-inflammatory activity, it can inhibit the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the s...
TMA1570	Sappanone A	Sappanone A is the first homoisoflavanone to be discovered with melanogenesis inhibitory activity. It exerts its anti-inflammatory effect by modulating the Nrf2 ...
TN4675	Nortrachelogenin	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN1485	Chicanine	Chicanine has anti-inflammatory activity in macrophages by down-regulating LPS-induced inflammatory cytokines in IκBα±/MAPK/ERK signaling pathways.
T14500	BAY-1316957	BAY-1316957 is a highly potent and selective EP4 receptor antagonist. With an IC50 of 15.3 nM. Good oral bioavailability[1].
TN3582	Canniprene	Canniprene has anti-inflammatory activity, it can potently inhibit the production of inflammatory eicosanoids via the 5-lipoxygenase pathway (IC50=0.4uM) and als...
T4624	PGD2-IN-1	PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d)
TN4592	Murrangatin	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the hig...
TN4420	Latifolin	Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-ÎºB activation via Nrf2-mediated heme oxygenase-1 expression. Latifol...
TN1171	6-Dehydrogingerdione	1-Dehydro-6-gingerdione is a 5-HT1A receptor partial agonist.
T16011	Manumycin A	Manumycin A is an antibiotic. Manumycin A induces apoptosis and exerts antitumor activity. Manumycin A inhibits exosome biogenesis and secretion via targeted inh...
T16389	Omidenepag	Omidenepag is a pharmacologically active form of Omidenepag Isopropyl and is a selective, non-prostanoid EP2 receptor agonist (EC50: 1.1 nM). Omidenepag displays...
TN5017	Sideritoflavone	Sideritoflavone has anti-inflammatory effect, it is a selective inhibitor of lipoxygenase activity in vitro.
T2S0765	Epibetulinic acid	Epibetulinic acid has anti-inflammatory activity, it exhibits potent inhibitory effects on NO and prostaglandin E(2) production in mouse macrophages (RAW 264.7) ...
TN5248	Voleneol	1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependent...
T13466	(+)-Talarozole	(+)-Talarozole is a potent retinoic acid metabolism inhibitor .
T15642	KAG-308	KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP...
T13488	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer. It can maintain the content of phospholipase A2 and pros...
T12100	MPGES1-IN-3	mPGES1-IN-3 is a potent and selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1) .
T14139	Aganepag	Aganepag is a potent Prostanoid EP2 receptor agonist, with an EC50 of 0.19 nM. It shows no activity at EP4 receptor. Aganepag can be used in the research of woun...
T10046	16,16-Dimethyl prostaglandin E2	16,16-Dimethyl prostaglandin E2 is an orally active vertebrate Hematopoietic stem cells homeostasis critical regulator. It can act through EP2/EP4 and has an int...
TN3366	Ailanthoidol	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potentia...
T11340	Furprofen	Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain. Furprofen is an non-steroidal anti-in...
TN3839	Desoxo-narchinol A	Desoxo-narchinol A exhibits protective effects against LPS-induced endotoxin shock and inflammation through p38 deactivation, it shows inhibitory activity agains...
TN2115	Pseudohypericin	Pseudohypericin has photocytotoxic, and antiretroviral activities, it has potential therapeutic value in diseases such as AIDS.
T15690	L-902688	L-902688 is an orally active EP4 receptor agonist (Ki: 0.38 nM; EC50: 0.6 nM). L-902688 displays >4,000-fold selective for EP4 over other EP and prostanoid recep...