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Prostaglandin Receptor

Prostaglandin receptors or prostanoid receptors represent a sub-class of cell surface membrane receptors that are regarded as the primary receptors for one or more of the classical, naturally occurring prostanoids viz., prostaglandin D2, , PGE2, PGF2alpha, prostacyclin (PGI2), thromboxane A2 (TXA2), and PGH2.[1] They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive to PGI2 at lower concentrations than any other prostanoid is named the Prostacyclin receptor (IP). One exception to this rule is the receptor for thromboxane A2 (TP) which binds and responds to PGH2 and TXA2 equally well.
Cat. No. 製品名 CAS No. Purity Chemical Structure
TN4675 Nortrachelogenin 34444-37-6 98%
Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl as...
T1978 GW627368 439288-66-1 98%
GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
T5150 Treprostinil 81846-19-7 98%
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T35610 2,5-dimethyl Celecoxib 457639-26-8 98%
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
T15712 Laropiprant 571170-77-9 98%
Laropiprant is a potent and selective DP receptor antagonist (Ki: 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively).
T9622 MF-766 1050656-06-8 98%
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1....
TQ0290 ONO-AE3-208 402473-54-5 98%
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
T3965 Fevipiprant 872365-14-5 98%
Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist.
T1338 Sucralfate 54182-58-0 98%
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
T15108 DG-041 861238-35-9 98%
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation ...
T4981 Anisotropine Methylbromide 80-50-2 98%
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T13703 Gestonorone Capronate 1253-28-7 98%
Gestonorone Capronate  is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer.
TN1134 Euscaphic acid 53155-25-2 98%
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
T5171 Treprostinil Sodium 289480-64-4 98%
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
T2538 Bimatoprost 155206-00-1 98%
Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
T1626 Prostaglandin E1 745-65-3 98%
Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that ...
T16280 Nedocromil 69049-73-6 98%
Nedocromil inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
T5841 Travoprost 157283-68-6 98%
Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
T28958 TG6-129 1164464-14-5 98%
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 red...
TQ0025 E7046 1369489-71-3 98%
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
Nortrachelogenin
TN4675
Nortrachelogenin ((-)-Wikstromol), which can be extracted from Partrinia scabiosaefolia, has antifungal activity and induces membrane disruption and cysteinyl as...
GW627368
T1978
GW627368X is a novel, potent and selective antagonist of prostanoid EP4 receptor.
Treprostinil
T5150
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
2,5-dimethyl Celecoxib
T35610
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1...
Laropiprant
T15712
Laropiprant is a potent and selective DP receptor antagonist (Ki: 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively).
MF-766
T9622
MF-766 is a highly potent, selective and orally active EP4 antagonist with a Ki of 0.23 nM. It behaves as a full antagonist with an IC50 of 1.4 nM (shifted to 1....
ONO-AE3-208
TQ0290
ONO-AE3-208 is an EP4 antagonist. It suppresses cell migration, invasion, and metastasis of prostate cancer.
Fevipiprant
T3965
Fevipiprant is a selective, potent, reversible competitive CRTh2 antagonist.
Sucralfate
T1338
Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.
DG-041
T15108
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation ...
Anisotropine Methylbromide
T4981
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
Gestonorone Capronate
T13703
Gestonorone Capronate  is a progesterone used to treat benign prostatic hyperplasia and endometrial cancer.
Euscaphic acid
TN1134
Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 w...
Treprostinil Sodium
T5171
Treprostinil is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).
Bimatoprost
T2538
Bimatoprost is a cloprostenol-derived amide that is used as an antihypertensive agent in the treatment of open-angle glaucoma and ocular hypertension.
Prostaglandin E1
T1626
Alprostadil is the naturally occurring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions. Alprostadil is a potent vasodilator agent that ...
Nedocromil
T16280
Nedocromil inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).
Travoprost
T5841
Travoprost is used to treat glaucoma and ocular hypertension,is a potent and selective FP prostaglandin receptor agonist.
TG6-129
T28958
TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 red...
E7046
TQ0025
E7046 is a specific, orally bioavailable EP4 antagonist (IC50: 13.5 nM, Ki: 23.14 nM), exhibiting anti-tumor activities.
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