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Proteasome

Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases.Proteasomes are part of a major mechanism by which cells regulate the concentration of particular proteins and degrade misfolded proteins.
Cat. No. 製品名 CAS No. Purity Chemical Structure
T16012 Marizomib 437742-34-2 98%
Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 2...
T7369L Gemigliptin Tartrate(911637-19-9 free base) 1374639-74-3 98%
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 n...
T26754 BC-23 6298-15-3 98%
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in th...
T36902 RA375 98%
RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater a...
T2401 Alogliptin Benzoate 850649-62-6 98%
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alog...
T2493 PD 151746 179461-52-0 98%
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
T17011 TCH-165 1446350-60-2 98%
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanc...
T16838 Saikogenin A 5092-09-1 98%
Saikogenin A is a dipeptidyl peptidase-4 inhibitor.
T3359 Aprotinin 9087-70-1 98%
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, ch...
T6432 Calpeptin 117591-20-5 98%
Calpeptin is a potent, cell-permeable calpain inhibitor.
T2296 Trelagliptin succinate 1029877-94-8 98%
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2...
T7369 Gemigliptin 911637-19-9
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
T7814 Alloxan monohydrate 2244-11-3
Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
T2470 MDL-28170 88191-84-8
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
T7133 Anagliptin 739366-20-2 100%
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
T6999 Teneligliptin hydrobromide 906093-29-6 100%
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
T12079 ML604440 1140517-08-3 95.24%
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
T2154 MG-132 133407-82-6 95.91%
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induc...
T8350 TPCK 402-71-1 96.77%
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
T21617 MG-115 133407-86-0 97.12%
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
Marizomib
T16012
Marizomib (ML858) is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L (β5), CT-T-laspase-like (C-L, β1), and trypsin-like (T-L, β2) 2...
Gemigliptin Tartrate(911637-19-9 free base)
T7369L
Gemigliptin Tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 n...
BC-23
T26754
BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity.BC-23 inhibits the CT-L activity of the proteasome and is used in th...
RA375
T36902
RA375 is a inhibitor of RPN13 (26S proteasome regulatory subunit). RA375 activates UPR signaling, ROS production and apoptosis. RA375 exhibits ten-fold greater a...
Alogliptin Benzoate
T2401
Alogliptin Benzoate (SYR 322)(SYR 322), an effective and specific DPP-4 inhibitor (IC50<10 nM), exhibits greater than 10, 000-fold selectivity over DPP-8/9. Alog...
PD 151746
T2493
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0...
TCH-165
T17011
TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanc...
Saikogenin A
T16838
Saikogenin A is a dipeptidyl peptidase-4 inhibitor.
Aprotinin
T3359
Aprotinin (Traskolan) a broad-spectrum serine protease inhibitor, inhibiting the activity of a number of different esterases and proteases, including trypsin, ch...
Calpeptin
T6432
Calpeptin is a potent, cell-permeable calpain inhibitor.
Trelagliptin succinate
T2296
Trelagliptin succinate (SYR-472 succinate) is a long-acting inhibitor of dipeptidyl peptidase-4 (DPP-4), being developed for the treatment of type 2 diabetes (T2...
Gemigliptin
T7369
Gemigliptin (LC15-0444) is a potent dipeptidyl peptidase-4 (DPP-4) inhibitor(KD : 7.25 nM.)
Alloxan monohydrate
T7814
Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.
MDL-28170
T2470
MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.
Anagliptin
T7133
Anagliptin (SK-0403) is a potent Inhibitor of DPP-4(IC50 of 3.8 nM), for the treatment of type 2 diabetes mellitus.
Teneligliptin hydrobromide
T6999
Teneligliptin hydrobromide (MP-513 (hydrobromide)) is a novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor; competitively inhibited human plasma, r...
ML604440
T12079
ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.
MG-132
T2154
MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induc...
TPCK
T8350
TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis
MG-115
T21617
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifi...
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