| T35694 |
OD36
|
1638644-62-8
|
98%
|
|
|
OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficien...
|
| T7397 |
GSK547
|
2226735-55-1
|
|
|
|
GSK547 (GSK'547) is a highly selective and potent inhibitor of RIP1 kinase,inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.
|
| T9702 |
Eclitasertib
|
2125450-76-0
|
|
|
|
Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).
|
| T7151 |
GSK2982772
|
1622848-92-3
|
|
|
|
GSK2982772 is an inhibitor of receptor interacting serine/threonine kinase 1 (RIPK1)with IC50 values of 16 nM and 20 nM for human and monkey RIP1, respectively.
|
| T15437 |
GSK3145095
|
1622849-43-7
|
100%
|
|
|
GSK3145095 is an orally active inhibitor of RIPK1 with IC50 of 5 nM, with potential immunomodulatory activities and antineoplastic.
|
| T11484 |
GSK2593074A
|
1337531-06-2
|
100%
|
|
|
GSK2593074A (GSK'074) is a programmed necrosis inhibitor that displays inhibitory effects on RIP1 and RIP3.
|
| T7795 |
RIPA-56
|
1956370-21-0
|
100%
|
|
|
RIPA-56 is an inhibitor of RIP1
|
| T9095 |
Necrostatin-34
|
375835-43-1
|
97%
|
|
|
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distin...
|
| T5054 |
GSK963
|
2049868-46-2
|
97.45%
|
|
|
GSK963 (Racemate), a structurally distinct, potent and selective inhibitor of RIP1 kinase(IC50=29 nM).
|
| T6815 |
HS-1371
|
2158197-70-5
|
98%
|
|
|
HS-1371 is a novel kinase inhibitor of receptor-interacting protein kinase 3 (RIP3) with an IC50 of 20.8 nM.
|
| T12731 |
RIPK1-IN-7
|
2300982-44-7
|
98.02%
|
|
|
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimen...
|
| T37558 |
Necrostatin-5
|
337349-54-9
|
98.03%
|
|
|
Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with T...
|
| T12493 |
PK68
|
2173556-69-7
|
98.13%
|
|
|
PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of in...
|
| T12728 |
RIP2 Kinase Inhibitor 3
|
1398053-50-3
|
98.35%
|
|
|
RIP2 Kinase Inhibitor 3 is a potent and selective inhibitor of RIP2 with an IC50 of 1 nM.
|
| T24152 |
HTH-01-091
|
2000209-42-5
|
98.40%
|
|
|
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
|
| T5401 |
GSK2983559 active metabolite
|
1423186-80-4
|
98.48%
|
|
|
GSK2983559 active metabolite (RIPK2-IN-1) is a potent, selective receptor-interacting protein-2 (RIP2) kinase inhibitor.
|
| T11492 |
GSK2983559 free acid
|
1579965-12-0
|
98.61%
|
|
|
GSK2983559 free acid is an effective and selective inhibitor of receptor-interacting protein 2 (RIP2). GSK2983559 free acid shows excellent activity in blocking ...
|
| T3537 |
GSK583
|
1346547-00-9
|
98.68%
|
|
|
GSK583 is a highly effective and specific RIP2 kinase inhibitor (IC50: 5 nM).
|
| T63055 |
RIPK1-IN-9
|
2682889-57-0
|
98.75%
|
|
|
RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respect...
|
| T9072 |
Tuxobertinib
|
2414572-47-5
|
98.86%
|
|
|
Tuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations(KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK a...
|
