| T12747 |
ROCK2-IN-2
|
1995065-79-6
|
98%
|
|
|
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
|
| T14521 |
BDP9066
|
2226507-04-4
|
98%
|
|
|
BDP9066 is a potent and selective MRCK inhibitor, inhibits MRCKβ and MRCKα/β, and can be used for the prevention and treatment of skin cancer.
|
| T7885 |
Afuresertib hydrochloride
|
1047645-82-8
|
100%
|
|
|
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
|
| T13419 |
ROCK-IN-1
|
934387-35-6
|
100%
|
|
|
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disor...
|
| T19913 |
CKI-7
|
1177141-67-1
|
100.00%
|
|
|
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
|
| T9652 |
SB-747651A Dihydrochloride
|
1781882-72-1
|
97.02%
|
|
|
SB-747651A dihydrochloride is a chemical compound that serves as an ATP-competitive inhibitor for mitogen- and stress-activated kinase 1 (MSK1), featuring an IC5...
|
| T6867 |
Belumosudil
|
911417-87-3
|
97.41%
|
|
|
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
|
| T10888 |
CRT0066854 hydrochloride
|
2250019-91-9
|
97.51%
|
|
|
CRT0066854 hydrochloride is an effective selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 valu...
|
| TQ0110 |
ROCK-IN-2
|
867017-68-3
|
97.59%
|
|
|
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
|
| T7301 |
BDP5290
|
1817698-21-7
|
98%
|
|
|
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
|
| T23308 |
SAR407899 hydrochloride
|
923262-96-8
|
98.01%
|
|
|
ATP-competitive ROCK inhibitor
|
| T77609 |
WAY-656935
|
852902-81-9
|
98.1%
|
|
|
WAY-656935 inhibits ROCK.
|
| T3513 |
GSK180736A
|
817194-38-0
|
98.16%
|
|
|
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
|
| T26078 |
Rhodblock 6
|
886625-06-5
|
98.27%
|
|
|
Rhodblock 6 is a Rho kinase (ROCK) inhibitor that inhibits the localization of phosphorylated MRLC (Myosin Regulatory Light Chain) and acts by specifically inhib...
|
| T38654 |
Cotosudil
|
1258833-31-6
|
98.41%
|
|
|
Cotosudil is a ROCK kinase inhibitor with antihypertensive activity and is used to treat or prevent diseases or conditions caused by cataracts, cardiovascular or...
|
| T15798 |
LX7101
|
1192189-69-7
|
98.42%
|
|
|
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
|
| T35328 |
H-1152 dihydrochloride
|
871543-07-6
|
98.42%
|
|
|
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochlo...
|
| T2633 |
GSK429286A
|
864082-47-3
|
98.42%
|
|
|
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
|
| T11402L |
GKI-1 HCl
|
T11402L
|
98.44%
|
|
|
GKI-1 HCl is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL and hGWL-KinDom.The inhibitory effect of GKI-1 HCl on ROCK1 is more significant.
|
| T4488 |
GSK-25
|
874119-56-9
|
98.59%
|
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
|
