ROCK

Rho-associated protein kinase (ROCK) is a kinase belonging to the AGC (PKA/ PKG/PKC) family of serine-threonine kinases. It is involved mainly in regulating the shape and movement of cells by acting on the cytoskeleton.

カタログ番号	製品名
T16855	SB-772077B dihydrochloride	SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).
T13972	Y-9738	Y-9738 is an agent of hypolipidemic.
T1606	Fasudil	Fasudil is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T13364	YAP/TAZ inhibitor-1	YAP/TAZ inhibitor-1 is an inhibitor of YAP/TAZ (IC50 of <0.100 μΜ in firefly luciferase assay).
T23308	SAR407899 hydrochloride	ATP-competitive ROCK inhibitor
T15808	Merestinib dihydrochloride	Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against M...
T35328	H-1152 dihydrochloride	H-1152 dihydrochloride is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits ...
T67748	ROCK-IN-5	ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferat...
TN1533	Cucurbitacin A	Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/RO...
T23888	CID-5056270	CID-5056270 is a ROCK2 enzyme inhibitor that is novel and potent.
T7552	H-1152	H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T22037	AS 1892802	AS 1892802 is a potent and selective inhibitor of ROCK. AS 1892802 exibits IC50 values of 52nM, 57nM and 122 nM for human ROCK2, rat ROCK2 and human ROCK1, respe...
T7492	Ripasudil free base	Ripasudil free base is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T12747	ROCK2-IN-2	ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T9652	SB-747651A Dihydrochloride	SB-747651A Dihydrochloride is an ATP-competitive mitogen- and stress-activated kinase 1 (MSK1) inhibitor with an IC50 of 11 nM. SB-747651A Dihydrochloride also i...
TQ0183	Narciclasine	Narciclasine, a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T7885	Afuresertib hydrochloride	Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T19913	CKI-7	CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
TQ0110	ROCK-IN-2	Azaindole 1 is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T7301	BDP5290	BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T2482	AT13148	AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T2633	GSK429286A	GSK429286A is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T3513	GSK180736A	GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), b...
T6867	Belumosudil	KD025 is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T2155	Thiazovivin	Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T7764	CCG-222740	CCG-222740 is an inhibitor of Rho/MRTF pathway
T4276L	Hydroxyfasudil	Hydroxyfasudil is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T14989	CMPD101	CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits ...
T2011	RKI1313	RKI-1313 was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T4488	GSK-25	GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
TQ0319	Ripasudil	Ripasudil (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T6057	URMC-099	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T13384L	Y-33075 dihydrochloride	Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T4095	ZINC00881524	ZINC00881524 is an effective and specific ROCK inhibitor.
T12721	Rho-Kinase-IN-1	Rho-Kinase-IN-1 is an inhibitor of ROCK with Kis of 30.5 nM and 3.9 nM for ROCK1 and ROCK2, respectively. Rho-Kinase-IN-1 can be used in studies about excessive ...
T3518	GSK269962A	GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T1898	RKI-1447	RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T6321	Tofacitinib	Tofacitinib is an oral, small molecule inhibitor of Janus kinases that is used to treat moderate-to-severe rheumatoid arthritis.
T1911	Afuresertib	Afuresertib is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T4276	Hydroxyfasudil Hydrochloride	Hydroxyfasudil hydrochloride is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T1870	Y-27632	Y-27632 is a selective ATP-competitive inhibitor of ROCK-I and ROCK-II.
T12746	ROCK inhibitor-2	ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
TQ0187	SR-3677	SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T14960	Chroman 1	Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T7391	SAR407899	SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T1725	Y-27632 dihydrochloride	Y-27632 is a selective inhibitor of ROCKs including p160ROCK (Ki: 140 nM) and ROCK2 (IC50: 800 nM).
T3060	Fasudil hydrochloride	Fasudil Hydrochloride is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T10358	Netarsudil Dihydrochloride	Netarsudil hydrochloride is an inhibitor of Rho-associated protein kinase (ROCK) and norepinephrine transporter (NET) with effective in intraocular pressure (IOP...
T9431	Y-39983 hydrochloride	Y-39983 hydrochloride is a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor.
T15798	LX7101	LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).