| T1903 |
Dabrafenib
|
1195765-45-7
|
98%
|
|
|
Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for...
|
| T24437 |
MCP110
|
521310-51-0
|
98%
|
|
|
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
|
| T76089 |
Pepinh-TRIF TFA
|
|
98%
|
|
|
Pepinh-TRIF TFA is a 30 aa peptide associated with the immune system that blocks TRIF signaling by interfering with TLR-TRIF interaction (TLR-TRIF interaction )....
|
| T1851 |
ZM 336372
|
208260-29-1
|
98%
|
|
|
ZM 336372 is a potent and selective c-Raf inhibitor.
|
| T63333 |
Uplarafenib
|
1425485-87-5
|
98%
|
|
|
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation...
|
| T5172 |
AZ304
|
942507-42-8
|
98%
|
|
|
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).
|
| T78183 |
B-Raf IN 15
|
832107-31-0
|
98%
|
|
|
B-Raf IN 15 is a BRAF inhibitor that inhibits BRAFWT and BRAFV600E and can be used in the study of melanoma and cancer, and can be optimized for use as a more ef...
|
| T2295 |
SB-590885
|
405554-55-4
|
|
|
|
SB590885 is an effective B-Raf inhibitor (Ki: 0.16 nM, in a cell-free assay). The selectivity of SB590885 for B-Raf is 11-fold greater over c-Raf, no acts to oth...
|
| T6948 |
Pluripotin
|
839707-37-8
|
|
|
|
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGA...
|
| T4167 |
Raf inhibitor 1 dihydrochloride
|
1191385-19-9
|
|
|
|
Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor.
|
| T3579 |
PLX8394
|
1393466-87-9
|
100%
|
|
|
PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both w...
|
| T9638 |
CCT241161
|
1163719-91-2
|
100%
|
|
|
CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays ...
|
| T3725 |
K-Ras(G12C) Inhibitor 6
|
2060530-16-5
|
100%
|
|
|
K-Ras(G12C) inhibitor 6 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24...
|
| T4194 |
Raf inhibitor 2
|
220904-99-4
|
100%
|
|
|
Raf inhibitor 2 (CID 25014542) is novel inhibitor of Raf kinases.
|
| T8402 |
Regorafenib Hydrochloride
|
835621-07-3
|
100%
|
|
|
Regorafenib Hydrochloride (BAY73-4506 hydrochloride) is a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with pote...
|
| T27454 |
GSK2008607
|
1244644-50-5
|
100%
|
|
|
GSK2008607 is a potent B-RafV600E inhibitor with anticancer activity and can be used to study breast, colorectal, melanoma, thyroid, and ovarian cancers.
|
| T6949 |
PLX7904
|
1393465-84-3
|
96.27%
|
|
|
PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRA...
|
| T15794 |
LUT014
|
2274819-46-2
|
96.34%
|
|
|
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
|
| T7414 |
ARS-853
|
1629268-00-3
|
96.64%
|
|
|
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
|
| T6320 |
GDC-0879
|
905281-76-7
|
96.74%
|
|
|
GDC-0879 (AR-00341677) is a novel, potent and selective B-Raf inhibitor with IC50 of 0.13 nM with activity against c-Raf as well.
|
