| T16432 |
Pan-RAS-IN-1
|
1835283-94-7
|
98%
|
|
|
Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors.
|
| T6844 |
GGTI298 Trifluoroacetate
|
1217457-86-7
|
98%
|
|
|
GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycl...
|
| T24437 |
MCP110
|
521310-51-0
|
98%
|
|
|
MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.
|
| T69529 |
BI-0474
|
2750570-55-7
|
98%
|
|
|
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antipr...
|
| T6483 |
EHT 1864
|
754240-09-0
|
|
|
|
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
|
| T1855 |
ZCL278
|
587841-73-4
|
|
|
|
ZCL278 is a selective Cdc42 GTPase inhibitor.
|
| T12979 |
BI-3406
|
2230836-55-0
|
100%
|
|
|
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
|
| T8843 |
APS6-45
|
2188236-41-9
|
100%
|
|
|
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
|
| T9198 |
SCH54292
|
188480-51-5
|
95.65%
|
|
|
SCH-54292 is a GDP exchange inhibitor.
|
| T12452 |
Digeranyl bisphosphonate
|
878143-03-4
|
96.07%
|
|
|
Digeranyl bisphosphonate (DGBP) is a potent geranylgeranyl pyrophosphate (GGPP) synthase inhibitor that inhibits geranyl pyrophosphorylation of Rac1.Digeranyl bi...
|
| T39738 |
ASP2453
|
2241719-73-1
|
96.57%
|
|
|
ASP2453 is a potent, selective and covalent inhibitor of KRAS G12C. ASP2453 inhibits the Son of Sevenless (SOS)-mediated interaction between KRAS G12C and Raf wi...
|
| T37422L |
Ras Inhibitory Peptide acetate
|
|
96.63%
|
|
|
Ras Inhibitory Peptide acetate is a peptide involved in the Ras-dependent signaling pathway that plays an important role in human cancers initiated by oncogenic ...
|
| T7414 |
ARS-853
|
1629268-00-3
|
96.64%
|
|
|
ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5 μM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells
|
| T5418 |
BAY-293
|
2244904-70-7
|
96.8%
|
|
|
BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).
|
| T8375 |
ML-210
|
1360705-96-9
|
97%
|
|
|
ML-210 (CID 49766530) is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
|
| T20759 |
XRP44X
|
729605-21-4
|
97.51%
|
|
|
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
|
| T2427 |
EHop-016
|
1380432-32-5
|
97.69%
|
|
|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
|
| T72084 |
(R)-BI-2852
|
2375482-49-6
|
97.78%
|
|
|
(R)-BI-2852 can be used as (R)-5-isoindolin-1-one is used as an inhibitor of the RAS family of proteins and as a compound for the treatment and prevention of tum...
|
| T10376 |
ARS-1630
|
1698055-86-5
|
97.81%
|
|
|
ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620.
|
| T5597 |
ZT-12-037-01
|
2328073-61-4
|
98%
|
|
|
Zt-12-037-01 is a ATP competitive STK19 inhibitor（IC50 values of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N),respectively).
|
