| T28589 |
Ro 41-5253
|
144092-31-9
|
98%
|
|
|
Ro 41-5253 is an orally active RARα antagonist, ligand and partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ. It exhibits antitumor activity...
|
| T14689 |
BMS493
|
215030-90-3
|
98%
|
|
|
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-...
|
| T3955 |
AR7
|
80306-38-3
|
|
|
|
AR7 is a retinoic acid receptor α (RARα) antagonist.
|
| T10261 |
AGN 196996
|
958295-17-5
|
|
|
|
AGN 196996 is a potent and selective inhibitor of RARα (Ki: 2 nM).AGN 196996 has very low affinity for RARβ and RARγ, with a Ki of 1087 nM and 8523 nM, respectiv...
|
| T7370 |
Talarozole
|
201410-53-9
|
|
|
|
Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5....
|
| T5843 |
Tarenflurbil
|
51543-40-9
|
100%
|
|
|
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as...
|
| T3000 |
Magnolol
|
528-43-8
|
100%
|
|
|
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
|
| T16425 |
PA452
|
457657-34-0
|
96.76%
|
|
|
PA452 is a selective antagonist of retinoic X receptor (RXR) and suppresses the effect of Retinoic acid on Th1/Th2 development.
|
| T6694 |
Tamibarotene
|
94497-51-5
|
97.22%
|
|
|
Tamibarotene (Amnolake) is an orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic a...
|
| T22192 |
BMS 195614
|
253310-42-8
|
97.7%
|
|
|
BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.
|
| T4538 |
Palovarotene
|
410528-02-8
|
98.05%
|
|
|
Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).
|
| T6410 |
Bexarotene
|
153559-49-0
|
98.12%
|
|
|
Bexarotene (LGD1069) is a retinoid analogue that is used to treat the skin manifestations of cutaneous T cell lymphoma (CTCL).
|
| T24240 |
K-8012
|
1346513-17-4
|
98.24%
|
|
|
K-8012 is a modulator of the N-terminally truncated RXRα and improves anticancer activities in an RXRα-dependent manner.
|
| T22920 |
LE135
|
155877-83-1
|
98.33%
|
|
|
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly select...
|
| T22049 |
BMS 753
|
215307-86-1
|
98.4%
|
|
|
BMS 753 is an agonist of isotype-selective retinoic acid receptor α (RARα, Ki= 2 nM).
|
| T14089 |
AC-261066
|
870773-76-5
|
98.44%
|
|
|
AC-261066 is an orally available and isoform-selective agonist of RARβ2 with a pEC50 of 8.0.
|
| T15811 |
LY2955303
|
1433497-19-8
|
98.56%
|
|
|
LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).
|
| T23005 |
MM 11253
|
345952-44-5
|
98.62%
|
|
|
MM 11253 is a RARγ antagonist with IC50 of 44nM.
|
| T14912 |
CD3254
|
196961-43-0
|
98.71%
|
|
|
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation.
|
| TQ0097 |
AGN 193109
|
171746-21-7
|
98.81%
|
|
|
AGN 193109, a retinoid analog, is a potent and specific antagonist of RARs (Kds: 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ).
|
