| T7391 |
SAR407899
|
923359-38-0
|
98%
|
|
|
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
|
| T9986 |
(E/Z)-ZINC09659342
|
591726-26-0
|
98%
|
|
|
(E/Z)-ZINC09659342 is an inhibitor of Lbc-Rho A interaction.
|
| T24833 |
ZINC69391
|
303094-67-9
|
98%
|
|
|
ZINC69391 (CysHHC10 acetate(1408311-03-4 free base)) is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes wit...
|
| T14004 |
1A-116
|
1430208-73-3
|
98%
|
|
|
1A-116 is a specific inhibitor of Rac1 .
|
| T6483 |
EHT 1864
|
754240-09-0
|
98%
|
|
|
EHT 1864 is a effective Rac family GTPase inhibitor for Rac1/Rac1b/Rac2/Rac3 (Kd: 40/50/60/250 nM).
|
| T37113 |
Z62954982
|
1090893-12-1
|
98%
|
|
|
Z62954982 (ZINC08010136) is a selective inhibitor of Rac1, which stunts the growth and branching of neurons.Z62954982 inhibits Rac1 activation and reduces prolif...
|
| T6739 |
Zoledronic Acid
|
118072-93-8
|
95.15%
|
|
|
Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma ...
|
| T2427 |
EHop-016
|
1380432-32-5
|
97.69%
|
|
|
EHop-016 is a specific Rac GTPase inhibitor with IC50 of 1.1 μM for Rac1 in MDA-MB-231 and MDA-MB-435 cells, equally effective inhibition for Rac3.
|
| T24642 |
YH-306
|
1373764-75-0
|
97.87%
|
|
|
YH-306 (TRV055 acetate ) is a modulator of the FAK signaling pathway that acts by suppressing colorectal tumor growth and metastasis.
|
| T8473 |
MLS000532223
|
16616-39-0
|
98.11%
|
|
|
MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).
|
| T3553 |
Y16
|
429653-73-6
|
98.26%
|
|
|
Y16 is a G-protein–coupled Rho GEFs inhibitor; works synergistically with Rhosin/G04 in inhibiting LARG-RhoA interaction, RhoA activation, and RhoA-mediated sign...
|
| T26193 |
SKLB-163
|
1255099-06-9
|
98.31%
|
|
|
SKLB-163 acts by downregulating RhoGDI, activating JNK-1 signaling pathway and caspase-3, and reducing phosphorylated Akt and p44/42 MAPK.
|
| T61448 |
AZA1
|
1071098-42-4
|
98.59%
|
|
|
AZA1 (Rac1/Cdc42-IN-1) is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induced apoptosis of prostate cancer cells and inhibited cell proliferation, migration ...
|
| T7764 |
CCG-222740
|
1922098-69-8
|
98.79%
|
|
|
CCG-222740 is an inhibitor of Rho/MRTF pathway
|
| T4306 |
CCG-203971
|
1443437-74-8
|
98.82%
|
|
|
CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This...
|
| T16745 |
Rhosin hydrochloride
|
1281870-42-5
|
98.92%
|
|
|
Rhosin hydrochloride is an effective and specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction (Kd: ~ 0...
|
| TP2131L |
Rac1 Inhibitor W56 acetate(1095179-01-3 free base)
|
TP2131L
|
98.96%
|
|
|
Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with...
|
| T15602 |
ITX3
|
347323-96-0
|
99.02%
|
|
|
ITX3 is a specific, non-toxic, active and selective TrioN RhoGEF inhibitor with IC50 of 76 μM. ITX3 has anticancer effects, inhibits trion mediated GTP exchange ...
|
| T25450 |
GGTI 2147
|
191102-87-1
|
99.32%
|
|
|
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis.
|
| T6342 |
NSC 23766 trihydrochloride
|
1177865-17-6
|
99.35%
|
|
|
NSC 23766 trihydrochloride (Rac1 Inhibitor) is an inhibitor of Rac GTPase targeting Rac activation by GEFs (IC50: ~50 μM); no inhibitory for the closely related ...
|
