| T6085 |
PF-543
|
1415562-82-1
|
98%
|
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
|
| T9992 |
SphK1&2-IN-1
|
1415662-57-5
|
98%
|
|
|
SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
|
| T21500 |
Sphingosine-1-phosphate
|
26993-30-6
|
98%
|
|
|
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
|
| T38294 |
4-Deoxypyridoxine hydrochloride
|
148-51-6
|
98%
|
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
|
| T27864 |
LX-2931
|
948840-25-3
|
100%
|
|
|
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
|
| T2026 |
CYM5442
|
1094042-01-9
|
96.65%
|
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
| T3961 |
CYM-5541
|
945128-26-7
|
97.34%
|
|
|
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.
|
| T10761 |
Ceranib-2
|
1402830-75-4
|
97.49%
|
|
|
Ceranib-2 (3-[(E)-3-(4-hydroxyphenyl)prop-2-enoyl]-4-phenyl-1H-quinolin-2-one) is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decr...
|
| T26866 |
BMS-960
|
1265321-86-5
|
97.74%
|
|
|
BMS-960 is an S1P agonist with potential anti-tumour activity for cancer research.
|
| T7360 |
GSK2018682
|
1034688-30-6
|
97.78%
|
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
| T6403 |
Siponimod
|
1230487-00-9
|
97.79%
|
|
|
BAF312 (Siponimod (BAF-312)), a next-generation S1P receptor modulator, is specific for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, respectively. T...
|
| T16128 |
MP-A08
|
219832-49-2
|
98.04%
|
|
|
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
|
| T9199 |
GLPG2938
|
2130996-00-6
|
98.1%
|
|
|
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and s...
|
| T22697 |
CS 2100
|
913827-99-3
|
98.13%
|
|
|
CS 2100 (1-[[4-Ethyl-5-[5-(4-phenoxyphenyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]-3-azetidinecarboxylic acid) is an S1P1 agonist.
|
| T22101 |
ML-031
|
852230-33-2
|
98.29%
|
|
|
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
|
| T27710 |
K6PC-5
|
756875-51-1
|
98.55%
|
|
|
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
|
| TQ0198 |
Phorbol 12-myristate 13-acetate
|
16561-29-8
|
98.55%
|
|
|
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
|
| T12437 |
PF429242 dihydrochloride
|
2248666-66-0
|
98.67%
|
|
|
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
|
| T22703 |
CYM-5520
|
1449747-00-5
|
98.72%
|
|
|
CYM-5520 is a noncompetitive allosteric agonist of S1P2
|
| T6750 |
Opaganib
|
915385-81-8
|
98.86%
|
|
|
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM).
|
