| T3079 |
GSK1838705A
|
1116235-97-2
|
98%
|
|
|
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
|
| T14072 |
A-443654
|
552325-16-3
|
98%
|
|
|
A-443654 is a pan-Akt inhibitor. A-443654 has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
|
| T6948 |
Pluripotin
|
839707-37-8
|
98%
|
|
|
Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGA...
|
| T7790 |
Bisindolylmaleimide V
|
113963-68-1
|
98%
|
|
|
Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.
|
| T6159 |
LY-2584702 free base
|
1082949-67-4
|
98%
|
|
|
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
|
| T5428 |
BIX 02565
|
1311367-27-7
|
98%
|
|
|
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
|
| T6878 |
LJI308
|
1627709-94-7
|
98%
|
|
|
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
|
| T6250 |
H-89 dihydrochloride
|
130964-39-5
|
100%
|
|
|
H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).
|
| T19913 |
CKI-7
|
1177141-67-1
|
100.00%
|
|
|
CKI-7 is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ...
|
| T6458 |
CYC-116
|
693228-63-6
|
96.6%
|
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
|
| T3074 |
CHIR 98024
|
556813-39-9
|
96.74%
|
|
|
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 ...
|
| T2608 |
CHIR-98014
|
252935-94-7
|
97.09%
|
|
|
CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
|
| T4327 |
Prexasertib dihydrochloride
|
1234015-54-3
|
97.5%
|
|
|
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2...
|
| T1961 |
Vistusertib
|
1009298-59-2
|
97.94%
|
|
|
Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
|
| T6877 |
LJH685
|
1627710-50-2
|
98%
|
|
|
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
|
| T1746 |
LY-2584702 tosylate salt
|
1082949-68-5
|
98.23%
|
|
|
LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
|
| T11961 |
MBM-55S
|
2083624-07-9
|
98.38%
|
|
|
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
|
| T2871 |
Quercitrin
|
522-12-3
|
98.4%
|
|
|
Quercitrin (3-rhamnosyl quercetin) is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a num...
|
| T4488 |
GSK-25
|
874119-56-9
|
98.59%
|
|
|
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
|
| T3518 |
GSK269962A
|
850664-21-0
|
98.63%
|
|
|
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
|
