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S6 Kinase

In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two subfamilies of rsk, p90rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70rsk, also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and S6K2.
カタログ番号 製品名
T11900 LY-2584702 hydrochloride Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
T11961 MBM-55S MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
T7790 Bisindolylmaleimide V Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
T24398 Lenaldekar Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
T14072 A-443654 A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T19913 CKI-7 CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T6458 CYC-116 CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
T1961 Vistusertib AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T6877 LJH685 LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
T2482 AT13148 AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T6250 H-89 dihydrochloride H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
T6159 LY-2584702 free base LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
T1746 LY-2584702 tosylate salt LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
T6948 Pluripotin Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
T6878 LJI308 LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
T3079 GSK1838705A GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T2871 Quercitrin Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
TN1712 Gossypin Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
T6S1302 Carnosol Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
T4488 GSK-25 GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
T14779 BRD7389 BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
T22422 S6K-18 S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.
T2608 CHIR-98014 CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
T6171 BI-D1870 BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).
T3518 GSK269962A GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T6304 AT7867 AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
T2002 PF-4708671 PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).
T4327 Prexasertib dihydrochloride Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respec...
T2265 Bimiralisib PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase i...
T4301 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
T3836 Eudesmin Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...
T0335 Sodium salicylate Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
T11960 MBM-55 MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
T3074 CHIR 98024 CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc2 ...
T6303 CCT128930 CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
TQ0310 FMK FMK is an irreversible inhibitor of RSK2 kinase.
T5428 BIX 02565 BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).
LY-2584702 hydrochloride
T11900
Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
MBM-55S
T11961
MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer ce...
Bisindolylmaleimide V
T7790
Bisindolylmaleimide V (BIM V) is a weak protein kinase C (PKC)inhibitor( IC50 >100 µM)
Lenaldekar
T24398
Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
A-443654
T14072
A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
CKI-7
T19913
CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
CYC-116
T6458
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
Vistusertib
T1961
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
LJH685
T6877
LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).
AT13148
T2482
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
H-89 dihydrochloride
T6250
H 89 is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 µM, Ki: 48 nM).
LY-2584702 free base
T6159
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
LY-2584702 tosylate salt
T1746
LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
Pluripotin
T6948
Pluripotin (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.
LJI308
T6878
LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.
GSK1838705A
T3079
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
Quercitrin
T2871
Quercitrin is a plant-derived flavonoid compound, displays antioxidant and anti-inflammatory activities. Quercitrin can be found in a number of food items such a...
Gossypin
TN1712
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the...
Carnosol
T6S1302
Carnosol has anti-oxidative, anti-inflammatory, antiproliferative and apoptosis inducing properties. Carnosol enhances the sensitivity of chemoresistant cancer c...
GSK-25
T4488
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically impr...
BRD7389
T14779
BRD7389 is an inhibitor of RSK family kinase with IC50s of 1.5 μM, 2.4 μM, and 1.2 μM for RSK1, RSK2, and RSK3, respectively.
S6K-18
T22422
S6K-18, a highly selective S6K1 inhibitor, inhibits S6K1 with IC50 of 52nM.
CHIR-98014
T2608
CHIR-98014 is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.
BI-D1870
T6171
BI-D1870 is a cell-permeable, ATP-competitive inhibitor of ribosomal S6 kinases (RSKs; IC50s: 31/24/18/15 nM for RSK1/2/3/4).
GSK269962A
T3518
GSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
AT7867
T6304
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the...
PF-4708671
T2002
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671 is potent for S6K1(Ki50=20 nM, IC50=160 nM).
Prexasertib dihydrochloride
T4327
Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respec...
Bimiralisib
T2265
PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase i...
AD80
T4301
AD80, a multikinase inhibitor, inhibits RET, RAF, SRCand S6K, with greatly reduced mTOR activity.
Eudesmin
T3836
Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 ...
Sodium salicylate
T0335
Sodium salicylate, a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress.
MBM-55
T11960
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing...
CHIR 98024
T3074
CHIR 98024 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM in cell-free assays, with the ability to distinguish GSK-3 from its closest homologs Cdc...
CCT128930
T6303
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinas...
FMK
TQ0310
FMK is an irreversible inhibitor of RSK2 kinase.
BIX 02565
T5428
BIX 02565 is a potent inhibitor of ribosomal S6 kinase 2 (RSK2, IC50: 1.1 nM).