| T28865 |
STAT3-IN-B9
|
825611-06-1
|
98%
|
|
|
STAT3-IN-B9 (B9) is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
|
| TN1013 |
Cucurbitacin D
|
3877-86-9
|
98%
|
|
|
Cucurbitacin D has anticancer effects, it induces apoptosis through caspase-3 and phosphorylation of JNK in hepatocellular carcinoma cells.
|
| T2S1040 |
Jolkinolide B
|
37905-08-1
|
98%
|
|
|
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can...
|
| T35544 |
ML115
|
912798-42-6
|
98%
|
|
|
ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
|
| T2S1975 |
Ponicidin
|
52617-37-5
|
98%
|
|
|
Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens. Ponicidin exhibits immunoregulatory, anti-inflammatory, anti-viral, and anti-cancer ...
|
| T11449L |
Golotimod
|
229305-39-9
|
98%
|
|
|
Golotimod is an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and spl...
|
| TN1673 |
Garcinone C
|
76996-27-5
|
98%
|
|
|
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcin...
|
| TN4379 |
Kansuinine A
|
57701-86-7
|
98%
|
|
|
Kansuinine A possesses analgesic props, it also shows NGF inducing activity.
|
| T9945 |
MNK8
|
2055078-49-2
|
98%
|
|
|
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) is a potent STAT3 inhibitor that reduces the ability of STAT3 to bind to DNA and also has a good g...
|
| T77672 |
JI069
|
850019-35-1
|
98%
|
|
|
JI069 (WAY-354189) is a potent STAT3 inhibitor that inhibits gp130 signaling by inducing dissociation between gp130 and JAK1.
|
| T4034 |
Solamargine
|
20311-51-7
|
|
|
|
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown t...
|
| T4234 |
HJC0152 hydrochloride
|
1420290-99-8
|
|
|
|
HJC0152 hydrochloride (HJC0152) is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
|
| TP1433 |
CMD178 TFA
|
TP1433
|
100%
|
|
|
CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.
|
| T8378 |
AS2863619
|
2241300-51-4
|
100%
|
|
|
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively).
|
| TJS1779 |
Protosappanin A
|
102036-28-2
|
100%
|
|
|
Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inf...
|
| T4672 |
Brevilin A
|
16503-32-5
|
100%
|
|
|
Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor a...
|
| T1038 |
Fludarabine
|
21679-14-1
|
100%
|
|
|
Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor...
|
| TQ0052 |
SH5-07
|
1456632-41-9
|
95.54%
|
|
|
SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
|
| T13009 |
STAT3-IN-1
|
2059952-75-7
|
95.89%
|
|
|
STAT3-IN-1 selective and orally active inhibitor of STAT3(in HT29 and MDA-MB 231 cells, with IC50 values of 1.82 μM and 2.14 μM , respectively), induces tumor ap...
|
| T9949 |
NSC 370284
|
116409-29-1
|
96.16%
|
|
|
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level o...
|
