| T6838 |
FLLL32
|
1226895-15-3
|
96.39%
|
|
|
FLLL32 is an effective JAK2/STAT3 inhibitor (IC50 of <5 μM).
|
| TP1856 |
Colivelin
|
867021-83-8
|
96.56%
|
|
|
Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
|
| TN1405 |
Arnicolide D
|
34532-68-8
|
96.66%
|
|
|
Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling path...
|
| T0711 |
Niclosamide
|
50-65-7
|
96.83%
|
|
|
Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.
|
| T13950 |
UC-514321
|
299420-83-0
|
97%
|
|
|
UC-514321 directly targets STAT3/5 and represses TET1 expression. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, wi...
|
| T19826 |
Rabeprazole
|
117976-89-3
|
97.06%
|
|
|
Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can b...
|
| T6995 |
Ochromycinone
|
111540-00-2
|
97.48%
|
|
|
Ochromycinone (STA 21) is a selective STAT3 inhibitor.
|
| T4605 |
NT157
|
1384426-12-3
|
97.55%
|
|
|
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal c...
|
| T5S0167 |
Atractylenolide I
|
73069-13-3
|
97.55%
|
|
|
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
|
| TN6739 |
Angoline
|
21080-31-9
|
97.9%
|
|
|
Angoline (6-Methoxyldihydrochelerythrine) hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosp...
|
| T2814 |
Cryptotanshinone
|
35825-57-1
|
98%
|
|
|
Cryptotanshinone (Cryptotanshinon), a STAT3 inhibitor (IC50: 4.6 μM) in a cell-free assay, strongly inhibits phosphorylation of STAT3 Tyr705, with a little effec...
|
| T5668 |
Triacetylresveratrol
|
42206-94-0
|
98%
|
|
|
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulate...
|
| T4216 |
STAT5-IN-1
|
285986-31-4
|
98%
|
|
|
STAT5-IN-1 (STAT5 Inhibitor) is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
|
| T16940 |
STAT5-IN-2
|
2111834-61-6
|
98.02%
|
|
|
STAT5-IN-2 is an inhibitor of STAT5 with antileukemic effects (EC50s: 9 μM and 5 μM in K562 and KU812 cells, respectively).
|
| T62105 |
NT219
|
1198078-60-2
|
98.06%
|
|
|
NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3, enhances the aggregation of misfolded prion protein NT219 affects the levels of c...
|
| T9339 |
Stafia-1
|
2582757-90-0
|
98.15%
|
|
|
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
|
| TQ0196 |
Cucurbitacin I
|
2222-07-3
|
98.2%
|
|
|
Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.
|
| T61030 |
STAT3-IN-11
|
2503096-50-0
|
98.3%
|
|
|
STAT3-IN-11 is a selective STAT3 inhibitor with inhibitory effects on phosphorylation of the STAT3pTyr705 site and phosphorylation of Survivin.STAT3-IN-11 promot...
|
| T3398 |
Icaritin
|
118525-40-9
|
98.50%
|
|
|
Icaritin (Anhydroicaritin) has hormone regulation activity and cardiovascular function improvement activity. Icaritin has anticancer activity, can induce S phase...
|
| TN1237 |
3-O-Methylgallic acid
|
3934-84-7
|
98.53%
|
|
|
3-O-Methylgallic acid (3,4-Dihydroxy-5-methoxybenzoic acid) reduces cell proliferation in Caco-2 cells(IC50 = 24.1 μM) more effectively than anthocyanins and may...
|
